256525-24-3

Upstream product

• 27318-90-7 1,10-phenanthroline-5,6-dione 
• 90-02-8 salicylaldehyde 
• 66-71-7 1,10-Phenanthroline 

Downstream Products

• 960378-77-2 [Ir(2-phenylpyridine(-H))2(2-(HOC₆H₄)imidazo[4,5-f][1,10]phenanthroline)]PF₆ 
• 1178520-61-0 [PtCl₂(2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanethroline)] 
• 1189566-19-5 C₃₃H₂₀N₈O₅RuS₂ 

Relevant academic research and scientific papers

Experimental and DFT studies on the vibrational and electronic spectra of 2-(1H-Imidazo [4,5-][1,10]phenanthrolin-2-yl)phenol

The compound 2-(1H-Imidazo [4,5-][1,10] phenanthrolin-2-yl) phenol (IPP) was synthesized, followed by structure determination by X-ray diffraction, the results of which agree well with the calculated optimized, lowest energy geometrical structure. Vibrati

Highly Selective Electrochemiluminescence Chemosensor for Sulfide Enabled by Hierarchical Reactivity

Hydrogen sulfide (H2S) is a well-known toxic gas with the odor of rotten eggs. Several reaction-based electrochemiluminescence (ECL) chemosensors for H2S have been developed; however, no homogeneous ECL probe with high selectivity toward H2S in aqueous media has been reported. Herein, we report an iridium(III) complex-based ECL chemodosimetric probe employing two 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) groups known as a photo-induced electron transfer quencher and a reaction site for the selective detection of H2S; the detection mechanism involves H2S being clearly distinguished from biothiols based on the different cleavage rates of the two NBD groups and extremely weak ECL interferences caused by reaction by-products. The probe was rationally designed to improve selectivity toward H2S within the ECL analysis platform by enabling the removal of nonspecific background signals observed via fluorescence analysis. This analytical system exhibited remarkable selectivity toward H2S, a rapid reaction rate, and high sensitivity (LOD = 57 nM) compared to conventional fluorescence methods. Furthermore, the probe could successfully quantify H2S in tap water samples and commercial ammonium sulfide solutions, which demonstrates the effectiveness of this probe in field monitoring.

Luminescent ruthenium(II)-para-cymene complexes of aryl substituted imidazo-1,10-phenanthroline as anticancer agents and the effect of remote substituents on cytotoxic activities

Ruthenium complexes are currently significant attention in medicinal chemistry as they offer various properties which make them an appropriate choice for drug development. Herein, a series of ruthenium(II)-p-cymene-2-aryl-imidazo-1,10-phenanthroline derivatives have been prepared and characterised by elemental analysis, infrared, LC-mass and NMR techniques. The structural and chemical properties shows that Ru(II) complexes have got rigidity, planarity, aromaticity, hydrogen donating and accepting capability which aids both solubility and interaction with biomolecules. The binding strength of these complexes with DNA and BSA were found to be 104–106 M?1. The competitive displacement of ethidium bromide (EtBr) from DNA in the presence of complex reveals an intercalation or groove binding further this was supported by viscosity and in-silico studies. The cytotoxicity study of these Ru(II) complexes were conducted with two cancer cell lines (MDA-MB-231 and HeLa) and one human embryonic kidney cells (HEK-293). The study revealed that [(η6-p-cymene)RuCl (κ2-N,N-2-(4-fluorophenyl)-1H-imidazo[4,5-f][1,10]Phenanthroline].PF6 (4e), [(η6-p-cymene)RuCl(κ2-N,N-2-(4-bromophenyl)-1H-imidazo[4,5-f][1,10]Phenanthroline].PF6 (4f) and [(η6-p-cymene)RuCl(κ2-N,N-2-(4-nitrophenyl)-1H-imidazo[4,5-f][1,10]Phenanthro line].PF6 (4g) were found exhibit least inhibitory concentration (IC50) and high selectivity with respect to HeLa and MDA-MB-231. The activity of the Ru(II) complexes were position and substituents dependent.

GSH-resistant and highly cytoselective ruthenium(ii)-p-cymene-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline

Luminescent heteroleptic Eu(iii) probes for the selective detection of diethyl chlorophosphate as a G-series nerve agent mimic in the vapor phase using solid-state films

The extreme toxicity of innocuous organophosphate (OP) nerve agents poses a significant public health risk. Developing an efficient sensing and detection system is crucial to contain and mitigate disasters and strengthen national security. Luminescence sp

Copper(i) ionic complexes based on imidazo[4,5-: F] [1,10]phenanthrolin diimine chelating ligands: Crystal structures, and photo- And electroluminescence properties

Four new ionic diimine Cu(i) complexes with general formula [Cu(POP)(NN)]BF4 have been synthesized by convenient methods from readily available starting materials. All the complexes were characterized by a range of spectroscopic, electrochemica

Synthesis, characterization, and nonlinear optical responses of nickel(ii) complexes with phenanthroline-based ligands

Three nickel(II) complexes with phenanthroline-based ligands were synthesized and characterized by UV-visible, IR, MS, and elemental analysis. Their off-resonance third-order nonlinear optical (NLO)properties were measured using a femtosecond laser and th

Photosensitizer and photovoltaic device

Disclosed is a novel photosensitizer that can absorb light in a wide visible light region and in the case of a very thin film form, can enhance a light absorption efficiency by virtue of a large light absorption coefficient. The photosensitizer is used fo

Synthesis, characterization, and DNA binding of complexes [Pt(bpy)(pip)]2+ and [Pt(bpy)(hpip)]2+

Two new platinum(II) complexes, [Pt(bpy)(pip)](NO3)2 (1) and [Pt(bpy)(hpip)](NO3)2·2H2O (2) (bpy is 2,2′-bypyridine; pip is 2-phenylimidazo[4,5-f][1,10] phenanthroline; hpip is 2-(2-hydroxyphenyl) imidazo[4,5-f][1,10]phenanthroline), have been synthesized and fully characterized by CHN analysis, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, 1H-NMR spectroscopy, IR spectroscopy (attenuated total reflection), and UV-vis spectroscopy. The DNA-binding behaviors of both complexes have been studied by spectroscopic methods and viscosity measurements, and their ability to inhibit DNA transcription was measured. The results indicate that both complexes show some degree of binding to DNA in an intercalative mode, resulting in intrinsic binding constants of (2.88 ± 0.4) × 104 and (5.38 ± 0.8) × 104 for 1 and 2, respectively. The comparatively observed difference in the DNA-binding affinities of the two complexes can be reasonably explained by the presence of intramolecular hydrogen bonding between the ortho phenolic group and the nitrogen atom of the imidazole ring. The extended coplanarity of the hpip ligand due to intramolecular hydrogen bonding may lead to an enhancement of the DNA-binding affinity of the hpip complex. In addition, the complexes can promote photocleavage of pUC19 DNA on irradiation as revealed by the spectroscopic and viscometric measurements, with 2 promoting cleavage of pUC19 DNA at lower concentration. Moreover, increasing concentrations of both complexes inhibited DNA transcription, and as expected 2 was shown to be a better antitumor agent than 1.

Potassium ferro-cyanide trihydrate complex catalyzed one-pot synthesis of 2-phenylimidazo [4,5-f] [1,10] phenanthroline

Various 2-phenylimidazo [4,5-f] [1,10] phenanthrolines were synthesized from potassium ferro-cyanide trihydrate (KFCT) complex catalyzed three component reaction of 1,10-phenanthroline-5,6-dione, aromatic aldehydes and ammonium acetate at room temperature in excellent isolated yield. This is a simple and straight forward, high yielding, not involving any hazardous or expensive catalyst method.