256526-06-4

Basic information

• Product Name: 2-Methoxy-6-(2-oxopropyl)benzonitrile
• Synonyms: 2-Methoxy-6-(2-oxopropyl)benzonitrile
• CAS NO: 256526-06-4
• Molecular Weight: 189.214
• Mol File: 256526-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Methoxy-6-(2-oxopropyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-6-(2-oxopropyl)benzonitrile(256526-06-4)
• EPA Substance Registry System: 2-Methoxy-6-(2-oxopropyl)benzonitrile(256526-06-4)

Safety Data

• Hazardous Substances Data: 256526-06-4(Hazardous Substances Data)

Upstream product

• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 53005-44-0 2-methoxy-6-methyl-benzonitrile 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 256526-07-5 (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile 

Relevant articles and documents

Chemoenzymatic synthesis of (S)-8-O-methylmellein by Candida parapsilosis carbonyl reductase

A screening of various orthosubstituted 2-oxopropylbenzene derivatives with carbonyl reductases and alcohol dehydrogenases, respectively, revealed that compounds containing ortho-substituents with only little steric demand are feasible substrates. (S)-8-O-Methylmellein (1) was synthesized by stereoselective enzymatic reduction of 2-methoxy-6-(2-oxopropyl)benzonitrile (5i) with Candida parapsilosis carbonyl reductase as the key step, and completed by a one-step hydrolysis and intramolecular cyclization.