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256530-26-4

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256530-26-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 256530-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,5,3 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 256530-26:
(8*2)+(7*5)+(6*6)+(5*5)+(4*3)+(3*0)+(2*2)+(1*6)=134
134 % 10 = 4
So 256530-26-4 is a valid CAS Registry Number.

256530-26-4Relevant articles and documents

β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

Liu, Na,Jensen, Anders A.,Bunch, Lennart

supporting information, p. 2212 - 2220 (2020/10/05)

The excitatory amino acid transporters (EAATs) mediate uptake of the major excitatory neurotransmitter l-glutamate (Glu). The essential functions governed by these transporters in regulating the central Glu level make them interesting therapeutic targets in a wide range of neurodegenerative and psychiatric disorders. l-Aspartate (Asp), another EAAT substrate, has served as a privileged scaffold for the development of EAAT inhibitors. In this study, we designed and synthesized the first β-indolyloxy Asp analogs 15a-d with the aim to probe a hitherto unexplored adjacent pocket to the substrate binding site. The pharmacological properties of 15a-d were characterized at hEAAT1-3 and rEAAT4 in a conventional [3H]-d-Asp uptake assay. Notably, thiophene analog 15b and the para-Trifluoromethyl phenyl analog 15d were found to be hEAAT1,2-preferring inhibitors exhibiting IC50values in the high nanomolar range (0.21-0.71 μM) at these two transporters versus IC50values in the low micromolar range at EAAT3,4 (1.6-8.9 μM). In summary, the results presented herein open up for further structure-Activity relationship studies of this new scaffold.

Effect of electron-withdrawing substituents on the epoxide ring: An experimental and theoretical electron density analysis of a series of epoxide derivatives

Grabowsky, Simon,Schirmeister, Tanja,Paulmann, Carsten,Pfeuffer, Thomas,Luger, Peter

, p. 1305 - 1318 (2011/04/23)

A series of acceptor-substituted epoxide derivatives is scrutinized by means of experimental and theoretical electron-density investigations. Due to the possibility of nucleophilic ring-opening, the epoxide ring is not only a very useful functional group in organic synthesis, but acceptor-substituted epoxides are valuable building blocks for the design of protease inhibitors. Therefore, the electron-density analysis in this work focuses on two main aspects that can contribute to rational drug design: (i) the quantification of the electron-withdrawing substituent effects on the epoxide ring and (ii) the intermolecular interactions involving the epoxide ring in combination with different substituents. It can be shown that the electron-withdrawing properties of the substituents cause an elongation of the C-C bonds in the epoxide rings and the loss of electron density can be measured by an analysis of critical points, atomic charges, and the source function. The different strengths of the substituents are reflected in these properties. Covalent and electrostatic contributions to the intermolecular interactions and thus the lattice energies are depicted on different molecular surfaces.(Figure Presented)

A revised mechanism for chemoselective reduction of esters with borane-dimethyl sulfide complex and catalytic sodium tetrahydroborate directed by adjacent hydroxyl group

Saito,Ishikawa,Kuroda,Koga,Moriwake

, p. 4067 - 4086 (2007/10/02)

The plausible mechanism for the reduction of the ester groups with a strong preference for one located α to the hydroxyl groups of (S)-malates and (R,R)-tartrate-based derivatives has been proposed together with some results with regard to its applications to the syntheses of chiral synthons.

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