2566-32-7

Usage

Uses

Used in Pharmaceutical Industry:
N-ME-DL-VAL-OH HCL is used as an intermediate for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Research and Development:
N-ME-DL-VAL-OH HCL is used as a research compound for studying the properties and interactions of N-methylated amino acids. This can lead to a better understanding of their role in various biological processes and the development of novel therapeutic strategies.
Used in Chemical Synthesis:
N-ME-DL-VAL-OH HCL is used as a building block in the chemical synthesis of complex organic molecules, including those with potential applications in the fields of medicine, agriculture, and materials science.
Used in Analytical Chemistry:
N-ME-DL-VAL-OH HCL can be used as a reference compound or standard in analytical chemistry for the identification and quantification of related compounds in various samples, such as pharmaceutical formulations or biological tissues.

Upstream product

• 1494680-68-0 ohmyungsamycin A 

Downstream Products

• 812788-74-2 (3R,6S)-3,6-diisopropyl-4-methyl-2,5-morpholinedione 
• 859800-36-5 N-methyl-N-DL-phenylacetyl-valine 
• 92619-25-5 N-Me-Cbz-valine 
• 42417-65-2 Z-MeVal-OH 
• 53978-73-7 Z-D-MeVal 
• 1007880-07-0 2-(benzyl(methyl)amino)-3-methylbutanoic acid trifluoroacetic acid salt 
• 408507-19-7 3-(N-methylamino)-4-methyl-2-pentanone 
• 150715-06-3 5-isopropyl-1-methyl-3-phenyl-2-thiohydantoin 
• 42492-62-6 2-(benzyl(methyl)amino)-3-methylbutanoic acid 
• 812788-12-8 (3S,6R)-3,6-diisopropyl-4-methyl-2,5-morpholinedione 
• 96893-60-6 DL-N-(4-Nitro-benzyoxycarbonyl)-N-methyl-valin 
• 4216-94-8 N-(4-Nitro-benzyloxycarbonyl)-N-methyl-L-valin 
• 13850-91-4 Boc-(D,L)-N(Me)-Val-OH 
• 56346-69-1 N-methyl-N-chloroacetyl-DL-valine 

Relevant academic research and scientific papers

Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens

A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A-D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey's analysis, chiral-phase GCMS, and chiral-phase HPLC. Dudawalamides A-D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure-activity relationship features of these NRPS-PKS-derived metabolites and their derivatives.

Ohmyungsamycins A and B: Cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island

Ohmyungsamycins A and B (1 and 2), which are new cyclic peptides, were isolated from a marine bacterial strain belonging to the Streptomyces genus collected from a sand beach on Jeju, a volcanic island in the Republic of Korea. Based on the interpretation of the NMR, UV, and IR spectroscopic and MS data, the planar structures of 1 and 2 were elucidated as cyclic depsipeptides bearing unusual amino acid units, including N-methyl-4-methoxytrytophan, β-hydroxyphenylalanine, and N,N-dimethylvaline. The absolute configurations of the α-carbons of the amino acid residues were determined using the advanced Marfey's method. The configurations of the additional stereogenic centers at the β-carbons of the threonine, N-methylthreonine, and β-hydroxyphenylalanine units were assigned by GITC (2,3,4,6-tetra-O-acetyl- β-d-glucopyranosyl isothiocyanate) derivatization and the modified Mosher's method. We have developed a new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline. Our first successful establishment of the absolute configuration of N,N-dimethylvaline using PGME will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups. Ohmyungsamycins A and B showed significant inhibitory activities against diverse cancer cells as well as antibacterial effects.

Two new 14-membered cyclopeptide alkaloids from Zizyphus xylopyra

The phytochemical investigation of the bark of Zizyphus xylopyra resulted in the isolation of two new 14-membered ring cyclopeptide alkaloids, xylopyrine-G and xylopyrine H. Their structures have been established by chemical and spectral evidences.