256650-49-4

Basic information

• Product Name: (2S,3S/R)-2-[4-(2-Chlorophenylmethoxycarbonylamino)butyl]-N-(2,4,6-trimethylphenylsulfonyl)-3-vinylaziridine
• Synonyms: (2S,3S/R)-2-[4-(2-Chlorophenylmethoxycarbonylamino)butyl]-N-(2,4,6-trimethylphenylsulfonyl)-3-vinylaziridine
• CAS NO: 256650-49-4
• Molecular Weight: 491.051
• Mol File: 256650-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S/R)-2-[4-(2-Chlorophenylmethoxycarbonylamino)butyl]-N-(2,4,6-trimethylphenylsulfonyl)-3-vinylaziridine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S/R)-2-[4-(2-Chlorophenylmethoxycarbonylamino)butyl]-N-(2,4,6-trimethylphenylsulfonyl)-3-vinylaziridine(256650-49-4)
• EPA Substance Registry System: (2S,3S/R)-2-[4-(2-Chlorophenylmethoxycarbonylamino)butyl]-N-(2,4,6-trimethylphenylsulfonyl)-3-vinylaziridine(256650-49-4)

Safety Data

• Hazardous Substances Data: 256650-49-4(Hazardous Substances Data)

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 256650-46-1 (2S)-6-(2-Chlorophenylmethoxycarbonylamino)-N-methoxy-N-methyl-2-(2,4,6-trimethylphenylsulfonylamino)hexanamide 
• 256650-47-2 [(S)-6-Oxo-5-(2,4,6-trimethyl-benzenesulfonylamino)-hexyl]-carbamic acid 2-chloro-benzyl ester 
• 42390-97-6 N^ε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine 
• 256650-48-3 (3S/R,4S)-8-(2-Chlorophenylmethoxycarbonylamino)-4-(2,4,6-trimethylphenylsulfonylamino)oct-1-en-3-ol 

Downstream Products

• 256650-50-7 Benzyl (2E,4R,5S)-9-(2-chlorophenylmethoxycarbonylamino)-4,5-[(2,4,6-trimethylphenylsulfonyl)epimino]non-2-enoate 

Relevant articles and documents

Regiospecific ring-opening reactions of β-aziridinyl ct, β-enoates with acids: Application to the stereoselective synthesis of a couple of diastereoisomeric (Zi)-alkene dipeptide isosteres from a single β-aziridinyl a, β-enoate and to the convenient preparation of amino alcohols bearing a, β-unsaturated ester groups

Regio- and stereo-selective ring-opening reactions of N-(2, 4, 6-trimethylphenylsulfonyl)-γ, δ-cis- or trans-γ, δ-epimino (E)-α, β-enoates with acids such as methanesulfonic acid (MSA) or trifluoroacetic acid (TFA) have been found. These ring-opening reactions are useful for the stereoselective synthesis of a couple of diastereomeric (￡)-alkene dipeptide isosteres from a single substrate of γ, δ-epimino (E)-α, β-enoate, and for the convenient preparation of δ-aminated γ-hydroxy α, β-enoates. The Royal Society of Chemistry 1999.