25680-53-9Relevant academic research and scientific papers
Stable isotope labeled 2 - methoxy -3 - isobutyl pyrazine synthesis method (by machine translation)
-
Paragraph 0013; 0033; 0037; 0041; 0045, (2018/09/12)
The invention relates to stable isotope labeled 2 - methoxy - 3 - isobutyl pyrazine synthetic method, bright ammonia amide hydrochloride as the raw material, after cooling with the glyoxal solution reaction, to obtain the 2 - hydroxy - 3 - isobutyl pyrazine, 2 - hydroxy - 3 - isobutyl pyrazine by the chlorinated reaction to obtain a pale yellow liquid 2 - chloro - 3 - isobutyl pyrazine, re-and stable isotope labeled methanol reaction, get colorless transparent liquid stable isotope-labeled 2 - methoxy - 3 - isobutyl pyrazine. Compared with the prior art, the process of the invention the procedure is short, the operation is simple, few by-products, the isotope abundance is not diluted and the like. (by machine translation)
Preparation of labelled 2-methoxy-3-alkylpyrazines: Synthesis and characterization of deuterated 2-methoxy-3-isopropylyrazine and 2-methoxy-3-isobutylpyrazine
Gerritsma, David A.,Brindle, Ian D.,Jones, Timothy R.B.,Capretta, Alfredo
, p. 243 - 253 (2007/10/03)
Efficient synthetic routes for a number of deuterated analogues of 2-methoxy-3-isopropylpyrazines and 2-methoxy-3-isobutylpyrazines have been developed involving the condensation of glyoxal with an α-amino acid amide followed by methylation with iodomethane. In this way [2H3]2-methoxy-3-isopropylpyrazine, 2-methoxy-3-isopropyl-[2H2]pyrazine, [2H3]2-methoxy-3-isopropyl- [2H2]pyrazine, [2H3]2-methoxy-3-isobutylpyrazine; 2-methoxy-3-isobutyl-[2H2]pyrazine and [2H3]2-methoxy-3-isobutyl- [2H2]pyrazine were prepared and characterized by NMR and MS. Copyright
