25683-71-0

Basic information

• Product Name: TERIZIDONE
• Synonyms: TERIZIDONE;4,4'-(p-Phenylenebis(methyleneamino))di-(isoxazolidin-3-one);4,4'-[1,4-Phenylenebis(methylidynenitrilo)]bis(isoxazolidin-3-one);Einecs 247-186-1;Terizidona;Terizidona [inn-spanish];Terizidonum;Terizidonum [inn-latin]
• CAS NO: 25683-71-0
• Molecular Formula: C₁₄H₁₄N₄O₄
• Molecular Weight: 302.29
• EINECS: 247-186-1
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 25683-71-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 204-205℃
• Appearance: /
• Density: 1.52
• Refractive Index: 1.691
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• PKA: 14.08±0.40(Predicted)
• CAS DataBase Reference: TERIZIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: TERIZIDONE(25683-71-0)
• EPA Substance Registry System: TERIZIDONE(25683-71-0)

Safety Data

• Hazardous Substances Data: 25683-71-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 25683-71-0 differently. You can refer to the following data:
1. TERIZIDONE is a drug used to treat tuberculosis.
2. A drug used to treat tuberculosis.

InChI:InChI=1/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+

Synthetic route

4,4'-{1,4-phenylenebis(methylidynenitrilo)}bis(isoxazolidin-3-one) (25683-71-0) + rhodium(III)chloride (10049-07-7) → Rh(trz)3Cl3*H2O (83616-92-6)

Conditions	Yield
In acetone reflux;

4,4'-{1,4-phenylenebis(methylidynenitrilo)}bis(isoxazolidin-3-one) (25683-71-0) + rhodium triiodide (15492-38-3) → Rh(trz)3I3*2H2O

Conditions	Yield
In acetone reflux;

4,4'-{1,4-phenylenebis(methylidynenitrilo)}bis(isoxazolidin-3-one) (25683-71-0) + rhodium(III) bromide (15608-29-4) → Rh(trz)3Br3*4H2O

Conditions	Yield
In acetone reflux;