25705-58-2

Upstream product

• 123-31-9 hydroquinone 
• 106-51-4 p-benzoquinone 
• 6363-31-1 2,4-dibromo-1,4-dihydroxybenzene 
• 5030-61-5 2,3-dibromo-1,4-dimethoxy benzene 

Downstream Products

• 1254339-12-2 (6,7-dibromo-5-hydroxy-benzofuran-3-yl)-(4-methoxyphenyl)-methanone 
• 1254339-30-4 (6,7-dibromo-5-hydroxy-benzofuran-3-yl)-(3,4-dimethoxy-phenyl)-methanone 
• 1254339-42-8 (6,7-dibromo-5-hydroxy-benzofuran-3-yl)-(3,4,5-trimethoxy-phenyl)methanone 

Relevant academic research and scientific papers

SCORPION VENOM BENZOQUINONE DERIVATIVES AND USES THEREOF

Provided are colored 1,4-benzoquinone compounds obtained by oxidation of precursor molecules from the venom of the scorpion Diplocentrus melici (Diplocentridae family). Schemes for the chemical synthesis of these compounds using reagents commercially available are also provided. Biological assays show that the red compound (3,5-dimethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione) is very effective at killing Staphylococcus aureus and that the blue compound (5-methoxy-2,3-bis(methylthio)cyclohexa-2,5-diene-1,4-dione) has remarkable activity against Mycobacterium tuberculosis. The blue compound is effective against multi-drug-resistant tuberculosis (MDR-TB) and is not detrimental to lung epithelium. Both compounds were found to be cytotoxic to human neoplastic cell lines and to mononuclear cells (PBMCs).

Photochromic coenzyme Q derivatives: Switching redox potentials with light

Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and is thus found in several cell compartments. We report a photochromic derivative of coenzyme Q that combines the molecular structures of the redox active cofactor and a photochromic dye. Light irradiation triggers an electronic rearrangement reversibly changing the redox potential. We used this effect to control the intermolecular redox reaction of the photochromic coenzyme Q derivative with dihydropyridine in solution by light irradiation. On mitochondria, the altered redox properties showed an effect on the respiratory chain. The experiments demonstrate that the redox reactions can be initiated inside the system of interest through irradiation with light and the accompanied photoisomerization.

BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS

The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF

Convenient preparations of the three 2,3-dihalo-1,4-benzoquinones

Efficient preparations of 2,3-dichloro-1,4-benzoquinone (1) and 2,3- dibromo-1,4-benzoquinone (2) from 1,4-benzoquinone are reported, as is the synthesis of the previously unknown 2,3-diiodo-1,4-benzoquinone (3) from 2.