2571-09-7

Basic information

• Product Name: N-(2,4-Dinitrophenyl)-3-nitrobenzaldehyde hydrazone
• Synonyms: 3-Nitrobenzaldehyde 2,4-dinitrophenyl hydrazone;N-(2,4-Dinitrophenyl)-3-nitrobenzaldehyde hydrazone
• CAS NO: 2571-09-7
• Molecular Formula: C₁₃H₉N₅O₆
• Molecular Weight: 331.2405
• Mol File: 2571-09-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 526.3°Cat760mmHg
• Flash Point: 272.1°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: N-(2,4-Dinitrophenyl)-3-nitrobenzaldehyde hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-Dinitrophenyl)-3-nitrobenzaldehyde hydrazone(2571-09-7)
• EPA Substance Registry System: N-(2,4-Dinitrophenyl)-3-nitrobenzaldehyde hydrazone(2571-09-7)

Safety Data

• Hazardous Substances Data: 2571-09-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H9N5O6/c19-16(20)10-3-1-2-9(6-10)8-14-15-12-5-4-11(17(21)22)7-13(12)18(23)24/h1-8,15H/b14-8+

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 619-25-0 3-Nitrobenzyl alcohol 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Downstream Products

• 99-61-6 3-nitro-benzaldehyde 

Relevant articles and documents

2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors

In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives 1-13 have been evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. Molecular Operating Environment (MOE) software was used for docking study. 2,4-Dinitrophenyl hydrazone 1-13 have been obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes in the presence of acetic acid act as a catalyst. The current results have shown that compounds 5 (IC50 =12.16μg/mL), 6 (IC50 =15.03μg/mL), and 12 (IC50 =16.42 μg/mL) have been found to be the more potent alpha amylase inhibitors as compared to the standard acarbose (IC50 = 42.47μg/mL). These compounds may provide better leads for alpha amylase inhibitor and further assessment of these compounds can be of great help in the discovery of new antidiabetic drugs.

Synthesis, structural characterization, and antioxidant activities of 2,4-dinitrophenyl-hydrazone derivatives

Thirty-two derivatives of 2,4-dinitro phenylhydrazone 1-32 were synthesized by one step reaction and characterized by spectroscopic techniques such as EI-MS and 1H-NMR. Compounds 1-32 were screened for their in vitro antioxidant activities. DPPH radical s

Structure-Reactivity correlation in the oxidation of substituted benzaldehydes by tetraethylammonium chlorochromate

Oxidation of 36 monosubstituted benzaldehydes by tetraethylammonium chlorochromate in dimethyl sulphoxide, leads to the formation of corresponding benzoic acids. The reaction is of first order with respect to chlorochromate and aldehydes. The reaction is promoted by H+; the H+ dependence has the form kobs = a + b[H+]. The oxidation of duteriated benzaldehyde exhibits substantial primary kinetic isotope effect. The reaction was studied in 19 different organic solvents and the effect of solvent was analyzed using Taft's and Swain's multiparametric equations. The rates of the oxidation of para- and meta-substituted benzaldehydes showed excellent correlation in terms of Charton's triparametric LDR equation, whereas the oxidation of ortho-substituted benzaldehydes were correlated well with tetraperametric LDRS equation. The oxidation of para-substituted benzaldehydes is more susceptible to the delocalized effect than is the oxidation of ortho- and meta- substituted compounds, which display a greater dependence on the field effect. The positive value of h suggests the presence of an electron-deficient reaction centre in the rate-determining step. The reaction is subjected to steric acceleration by the orthosubstituents. A suitable mechanism has been proposed.