2572-58-9Relevant academic research and scientific papers
Palladium-Catalyzed Enantioselective 1,1-Fluoroarylation of Aminoalkenes
He, Ying,Yang, Zhenyu,Thornbury, Richard T.,Toste, F. Dean
, p. 12207 - 12210 (2015/10/12)
The development of an enantioselective palladium-catalyzed 1,1-fluoroarylation of unactivated aminoalkenes is described. The reaction uses arylboronic acids as the arene source and Selectfluor as the fluorine source to generate benzylic fluorides in good yields with excellent enantioselectivities. This transformation, likely proceeding through an oxidative Heck mechanism, affords 1,1-difunctionalized alkene products.
