257292-28-7Relevant articles and documents
Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay
Drewe, John,Kasibhatla, Shailaja,Tseng, Ben,Shelton, Emma,Sperandio, David,Yee, Robert M.,Litvak, Joane,Sendzik, Martin,Spencer, Jeffrey R.,Cai, Sui Xiong
, p. 4987 - 4990 (2008/02/10)
We report the discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-(4-methylphenyl)-(E)-2,3,6,7-tetrahydro-1,4-thiazepine (2a) as an inducer of apoptosis using our proprietary cell- and caspase-based HTS assay. Through structure activity relationship