25741-48-4Relevant academic research and scientific papers
Syntheses and DNA photocleavage by mono- and bis-phenothiazinium-piperazinexylene intercalators
Wilson, Beth,Fernández, María-José,Lorente, Antonio,Grant, Kathryn B.
, p. 3429 - 3436 (2008/09/20)
Chromophore systems consisting of one (compound 5) or two (compound 6) phenothiazine rings covalently attached to a bis-piperazinexylene chain were synthesized and evaluated as DNA photocleaving agents. In the presence of DNA, the compounds were shown to
Design and Synthesis of RNA-Specific Groove-Binding Cations: Implications for Antiviral Drug Design
McConnaughie, Adrian W.,Spychala, Jaroslaw,Zhao, Min,Boykin, David,Wilson, W. David
, p. 1063 - 1069 (2007/10/02)
As as initial step in the design of structure-specific RNA-interactive molecules as potential antiviral agents, we have focused on the synthesis of molecules that exhibit strong and preferential binding to douplex RNA.A series of polycationic ligands have
