25742-66-9

Upstream product

• 25742-90-9 5-acetoxy-3-(2,6-dichloro-phenyl)-4,5-dihydro-isoxazole 
• 25742-62-5 3-(2,6-dichlorophenyl)-5-hydroxy-2-isoxazoline 
• 35167-28-3 vinyl phenyl selenide 
• 2904-62-3 2,6-dichlorobenzonitrile N-oxide 
• 25185-95-9 2,6-dichlorobenzaldoxime 
• 76439-08-2 C₁₈H₂₃Cl₂N₃O₃ 

Relevant academic research and scientific papers

Traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines using polystyrene-supported vinyl selenide

A novel facile procedure for the traceless solid-phase synthesis of 3-substituted isoxazoles and 3-substituted 5-iodoisoxazolines in good yields and with excellent purities using polymer-supported vinyl selenide is described. The polymeric reagent can be

One-Pot Synthesis of 3-Substituted Isoxazoles from Phenyl Vinylic Selenide

Phenyl vinylic selenide was adopted for 1,3-dipolar cycloaddition to nitrile oxides and subsequent oxidation-elimination furnished 3-substituted isoxazoles with good yields in a one-pot, two-step transformation.

SYNTHESIS OF 3-ARYL-4,5-DIHYDRO-5-HYDROXY-1,2-OXAZOLES BY REACTION OF SUBSTITUTED BENZONITRILE OXIDES WITH THE ENOLATE ION OF ACETALDEHYDE.

By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n-butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields.Treatment of such hydroxy-isoxalines with some common bases allows their conversion in high yields into the corresponding isoxazoles.

4,5-DIHYDROISOXAZOLES. IV. 4- AND 5-PHENYLTHIO-4,5-DIHYDROISOXAZOLES AND THEIR BEHAVIOUR WITH PERFORMIC ACID

Several cis- and trans-4,5-dihydroisoxazole derivatives bearing a phenylthio group on C(4) or C(5) have been prepared by cyclo-addition of the corresponding unsaturated sulphides and nitrile oxides.The cyclo-adducts have been oxidized by HCOOH/H2O2.It has been shown that this oxidation leads mainly to isoxazole derivatives (i.e. is accompanied by elimination) when the sulphur-containing substituent is bound to C(5).The 4-phenylthio-substituted regioisomers gave in most cases the corresponding sulphones.

5-Amino-4,5-dihydroisoxazoles. Part I. 5-Amino-3-aryl-4-methylene-4,5-dihydroisoxazoles and 4-Aminomethyl-3-arylisoxazoles from 5-Amino-4-aminomethyl-3-aryl-4,5-dihydroisoxazoles

5-Amino-4-aminomethyl-3-aryl-4,5-dihydroisoxazoles 2 were obtained by cycloaddition of nitrile oxides to 1,3-diaminopropenes 1.On reaction with methyliodide the corresponding 4-(quaternary)-ammoniomethyl iodides 3 were formed.These compounds, on reaction