25755-84-4Relevant academic research and scientific papers
Organocatalyzed nucleophilic addition of pyrazoles to 2: H -azirines: Asymmetric synthesis of 3,3-disubstituted aziridines and kinetic resolution of racemic 2 H -azirines
An, Dong,Guan, Xukai,Guan, Rui,Jin, Lajiao,Zhang, Guangliang,Zhang, Suoqin
, p. 11211 - 11214 (2016)
The first organocatalytic asymmetric nucleophilic addition of arylpyrazoles to 2H-azirines and kinetic resolution of racemic 2H-azirines have been realized. Chiral aziridines were obtained with up to 98% yields and up to 99.9% ee. Meanwhile, simply changing the ratio of reactants, optically active 2H-azirines were recovered in good yields with excellent enantioselectivities.
An Azirine Strategy for the Synthesis of Alkyl 4-Amino-5-(trifluoromethyl)-1 H -pyrrole-2-carboxylates
Funt, Liya D.,Tomashenko, Olesya A.,Novikov, Mikhail S.,Khlebnikov, Alexander F.
, p. 4809 - 4822 (2018/12/13)
1-(3,3,3-Trifluoro-2,2-dihydroxypropyl)pyridin-1-ium bromide serves as a trifluoromethyl-containing building block for the preparation of trifluoromethyl-substituted aminopyrroles based on the 2 H -azirine ring expansion strategy. The primary products, 3-
