257619-72-0

Basic information

• Product Name: (E)-(1'S)-2,3-dihydro-3-(2-oxo-2-phenylethylidene)-2-(1'-phenylethyl)-1H-isoindol-1-one
• Synonyms: (E)-(1'S)-2,3-dihydro-3-(2-oxo-2-phenylethylidene)-2-(1'-phenylethyl)-1H-isoindol-1-one
• CAS NO: 257619-72-0
• Molecular Weight: 353.42
• Mol File: 257619-72-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-(1'S)-2,3-dihydro-3-(2-oxo-2-phenylethylidene)-2-(1'-phenylethyl)-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(1'S)-2,3-dihydro-3-(2-oxo-2-phenylethylidene)-2-(1'-phenylethyl)-1H-isoindol-1-one(257619-72-0)
• EPA Substance Registry System: (E)-(1'S)-2,3-dihydro-3-(2-oxo-2-phenylethylidene)-2-(1'-phenylethyl)-1H-isoindol-1-one(257619-72-0)

Safety Data

• Hazardous Substances Data: 257619-72-0(Hazardous Substances Data)

Upstream product

• 3976-26-9 2-((S)-1-phenylethyl)-isoindoline-1,3-dione 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Diastereoselective alkylation of aromatic enamidone functionality in isoindole series: A convenient route to chiral aza-analogues of Senkyunolide- E

Chiral aza-analogues (2a) and (2b) of Senkyunolide-E were efficiently synthesized in a four-step sequence (72 and 70 % overall yields respectively) from the commercially available phthalic anhydride and (S)-(-)-α- phenylethylamine. The key step consisted in the 1,2-addition of Grignard reagents onto enamidone type compounds (8) and (9). These latters were regioselectively obtained from the parent ω-alkynyl-ω-carbinol lactams (6) and (7) by a Meyer-Schuster rearrangement.