25771-65-7

Usage

Uses

Used in Pharmaceutical Industry:
8-nitro-4-phenylquinoline is used as a pharmaceutical candidate for its potential antimicrobial and antineoplastic activities. Its ability to target and inhibit the growth of certain microorganisms and cancer cells makes it a promising compound for the development of new drugs and therapies.
Used in Research and Development:
8-nitro-4-phenylquinoline is used as a fluorescent probe for detecting and studying biomolecules. Its unique properties allow researchers to track and analyze the behavior of various biological molecules, contributing to a better understanding of biological processes and the development of new diagnostic tools.
Used in Organic Synthesis:
8-nitro-4-phenylquinoline is used as a building block in organic synthesis, enabling the development of new pharmaceuticals and materials. Its versatile structure allows for the creation of a wide range of compounds with diverse applications in various industries.
Used in Material Science:
8-nitro-4-phenylquinoline is used in the development of new materials, leveraging its unique properties to create innovative products with enhanced performance characteristics. Its potential applications in material science include the creation of advanced materials for use in electronics, coatings, and other industries.

InChI:InChI=1/C15H10N2O2/c18-17(19)14-8-4-7-13-12(9-10-16-15(13)14)11-5-2-1-3-6-11/h1-10H

Upstream product

• 607-35-2 8-nitroquinoline 
• 71-43-2 benzene 
• 936-59-4 3-chloropropiophenone 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 55484-55-4 8-Amino-4-phenylquinoline 
• 62366-01-2 4-phenyl-1,10-phenanthroline 
• 1662-01-7 bathophenanthroline 
• 103542-42-3 methyl 5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentanoate 
• 103542-41-2 5-(4-(7-phenyl-1,10-phenanthrolin-4-yl-κN1,κN10)phenyl)pentanoic acid 

Relevant academic research and scientific papers

2,9-dichloro-4,7-diphenyl-1,10 phenanthroline

The invention relates to 2,9-dichloro-4,7-diphenyl-1,10 phenanthroline, which belongs to the technical field of synthesis of organic chemistry. A method comprises the steps of: firstly mixing and stirring 8-nitroquinoline with sulfuric acid, dropwise adding benzene while stirring, mixing SnCl2.2H2O with acetic acid, and then adding into the reaction mixture, after stirring and mixing, inflating nitrogen gas, stirring, rising temperature, performing heat preservation, cooling to room temperature, dropwise adding sodium hydroxide under stirring, mixing with the acetic acid, adding potassium permanganate, stirring at constant temperature, adding benzoyl chloride, then slowly pouring the reaction mixture into icy water, introducing chlorine after stirring, sealing for reaction, and adding the sodium hydroxide, filtering, extracting filtrate and filtrate slag with hot benzene, combining the extract liquor, adding anhydrous sodium sulfate for drying, rotating to evaporate the benzene, and performing suction filtration. The invention has the beneficial effects of simple synthetic conditions, no secondary pollution, less side productions and a yield of more than 86%.

A new robust and highly sensitive FRET donor-acceptor pair: Synthesis, characterization, and application in a thrombin assay

The synthesis of a new, robust fluorescence-resonance-energy-transfer (FRET) system is described. Its donor chromophore is derived from an N-allyl-substituted quinolinone attached to 4-bromophenyl-alanine via Heck cross-coupling. The resulting Fmoc-protected derivative 11 was used as building block in solid-phase peptide synthesis (SPPS). As FRET acceptor, a sulfonylated ruthenium(II)-bathophenanthroline complex with a peripheral COOH function was prepared for covalent attachment to target molecules. The UV/VIS absorption and emission spectra of peptides bearing only the donor (D) or acceptor (A) dye showed a good overlap of the emission band of the donor with the absorption band of the acceptor. The fluorescence spectra of a peptide bearing both dyes revealed an additional emission after excitation of the donor, which is due to indirect excitation of the acceptor via FRET. The long fluorescence lifetime of the RuII complex (0.53 μs) makes it well-suited for time-resolved measurements. As a first application of this new FRET system, the peptide 18, with the recognition sequence for the protease thrombin, flanked by the two dyes, was synthesized and successfully cleaved by the enzyme. The change in the ratio of the fluorescence intensities could be determined.