25783-69-1

Upstream product

• 6332-83-8 2-(4-chlorophenyl)-1-phenylethanone 
• 36122-12-0 2,3-bis(4-chlorophenyl)-1,4-diphenylbutane-1,4-dione 

Relevant academic research and scientific papers

Silver-Catalyzed Coupling of Two Csp3-H Groups and One-Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles

Silver-catalyzed coupling of two Csp3-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization to synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as the terminal oxidant and readily accessible starting materials, displays a wide substrate scope and broad functional-group tolerance.