257874-86-5 Usage
Molecular structure
2-1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-1H-indol-3-yl-acetamide has a complex structure that includes an indole ring and an acetamide group.
Silicon-containing functional group
The compound contains a tert-butyl-dimethyl-silanyloxy moiety, which is a silicon-containing functional group.
Properties and applications
The compound is likely to have properties and applications that are characteristic of both the indole and acetamide functional groups.
Reactivity
The presence of the silicon-containing moiety may contribute to the compound's reactivity.
Unique structure
The combination of functional groups in this compound makes it potentially interesting for various applications.
Organic synthesis
The compound may be useful in organic synthesis due to its unique structure and reactivity.
Pharmaceutical research
The compound may have potential applications in pharmaceutical research due to its combination of functional groups and reactivity.
Other applications in chemistry
The compound's unique structure and properties may make it suitable for various applications in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 257874-86-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,8,7 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 257874-86:
(8*2)+(7*5)+(6*7)+(5*8)+(4*7)+(3*4)+(2*8)+(1*6)=195
195 % 10 = 5
So 257874-86-5 is a valid CAS Registry Number.
257874-86-5Relevant articles and documents
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors
Ye, Qing,Xu, Guiqing,Lv, Dan,Cheng, Zhe,Li, Jia,Hu, Yongzhou
experimental part, p. 4302 - 4312 (2009/10/10)
A series of novel 4-azaindolyl-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high potency to GSK-3β. Among them, compound 7c was the most promising GSK-3β inhibitor. Preliminary structure-activity relationships were discussed based on the experimental data obtained and showed that different substituents on the indole ring and side chains at 1-position of indole had varying degrees of influence on the GSK-3β inhibitory potency. In a cell-based functional assay, compounds 7c and 15a significantly reduced Aβ-induced Tau hyperphosphorylation by inhibiting GSK-3β.
KINASE INHIBITORS
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Page/Page column 40, (2010/02/07)
The present invention provides kinase inhibitors of Formula (I)