257891-66-0Relevant articles and documents
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 4
Ho,Kukla,Breslin,Ludovici,Grous,Diamond,Miranda,Rodgers,Ho,De Clercq,Pauwels,Andries,Janssen,Janssen
, p. 794 - 802 (2007/10/02)
In previous papers, we have described the discovery of a new series of compounds, 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-ones, TIBO (1 and 1a), with potent anti-HIV-1 activity and the synthesis of analogues to better define
Regioselectivity in Intramolecular Nucleophilic Aromatic Substitution. Synthesis of the Potent Anti HIV-1 8-Halo TIBO Analogues
Parker, Kathlyn A.,Coburn, Craig A.
, p. 97 - 100 (2007/10/02)
Regioselective intramolecular nucleophilic substitution of 2,6-dihalo-3-nitrobenzyl diamines 2b and 2c gave benzodiazepines 3.These intermediates are useful in the preparation of the 8-halo TIBO derivatives 1, inhibitors of HIV-I replication in cell cultu