257892-31-2 Usage
Description
N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 | 71742 | 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.
Chemical Properties
White Solid
Check Digit Verification of cas no
The CAS Registry Mumber 257892-31-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,8,9 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 257892-31:
(8*2)+(7*5)+(6*7)+(5*8)+(4*9)+(3*2)+(2*3)+(1*1)=182
182 % 10 = 2
So 257892-31-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H17N3O3S/c21-16-14(24-17(22)20-16)11-12-4-6-13(7-5-12)23-10-9-19-15-3-1-2-8-18-15/h1-8,14H,9-11H2,(H,18,19)(H,20,21,22)
257892-31-2Relevant articles and documents
Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5
Kaspera, Ruediger,Naraharisetti, Suresh B.,Evangelista, Eric A.,Marciante, Kristin D.,Psaty, Bruce M.,Totah, Rheem A.
, p. 681 - 691 (2011)
Genetic polymorphisms in CYP2C8 can influence the metabolism of important therapeutic agents and cause interindividual variation in drug response and toxicity. The significance of the variant CYP2C8*3 has been controversial with reports of higher in vivo
