257928-43-1

Basic information

• Product Name: (R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine
• Synonyms: (R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine;1,2,3,6-Tetrahydro-1-[(1R)-1-phenylethyl]-4-[4-(phenylmethoxy)phenyl]pyridine
• CAS NO: 257928-43-1
• Molecular Formula: C₂₆H₂₇NO
• Molecular Weight: 369.505
• Mol File: 257928-43-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 507.449 °C at 760 mmHg
• Flash Point: 146.619 °C
• Appearance: /
• Density: 1.108
• Storage Temp.: 2-8°C
• PKA: 7.87±0.40(Predicted)
• CAS DataBase Reference: (R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine(257928-43-1)
• EPA Substance Registry System: (R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine(257928-43-1)

Safety Data

• Hazardous Substances Data: 257928-43-1(Hazardous Substances Data)

Usage

General Description

"(R)-4-(4-(benzyloxy)phenyl)-1-(1-phenylethyl)-1,2,3,6-tetrahydropyridine" is a full label for a specific class of organic compounds that belong to the category of alkaloids and derivatives. It contains a tetrahydropyridine ring system (four hydrogen atoms attached to a six-membered nitrogenous ring), which has potential biological activity. This chemical compound is mainly characterized by the presence of two phenyl groups and a benzyloxy group attached to the ring system. Also, the "(R)" in the name signifies the relative configuration of the attached groups, implying that it is one of two possible stereoisomers. Although the specific uses or reactions involving this chemical are not stated, these types of complex organic molecules are commonly found in pharmaceuticals, materials science, and organic chemistry research.

Upstream product

• 94571-13-8 1-methyl-1-<4-(benzyloxy)phenyl>ethanol 
• 10277-86-8 (R)-1-phenylethylamine hydrochloride 
• 257928-44-2 1-(benzyloxy)-4-(prop-1-en-2-yl)benzene 
• 37497-65-7 2-piperideine 
• 6153-56-6 oxalic acid dihydrate 
• 50-00-0 formaldehyd 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 257928-40-8 (1R,6R)-6-(4-benzyloxy-phenyl)-3-[(R)-1-phenyl-ethyl]-7-oxa-3-aza-bicyclo [4.1.0] heptane 
• 257938-64-0 (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 303043-23-4 (3S,4R,5R)-3-((R)-2,3-Dihydroxy-propoxy)-4-{4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl}-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-21-2 (3S,4R,5R)-3-[(4S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-27-8 (3S,4R,5R)-3-[(2R)-2-hydroxy-3-methoxy-propoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 304025-82-9 (3R,4R)-3-[1-(2-acetylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-26-7 (3R,4R,5S)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(4-methoxy-naphthalen-2-ylmethoxy)-5-[(2R)-oxiranylmethoxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-22-3 (R)-3-[(3S,4R,5R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidin-3-yloxy]-propane-1,2-diol 
• 304025-53-4 Ro 661168 
• 257938-73-1 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(1,2,3,4-tetrahydro-quinolin-7-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 257938-72-0 (3R,4R)-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-3-(quinolin-7-yl-methoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-19-8 (3S,4R,5R)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-5-hydroxy-4-{4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 303043-16-5 (3R,4R,5S)-4-(4-Benzyloxy-phenyl)-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 257938-68-4 (3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Process and intermediates for preparation of substituted piperidine-epoxides

The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof comprisingepoxidation of a compound of formula 2 or a salt thereof wherein A, R1and R2are as herein

Piperidine renin inhibitors: from leads to drug candidates

Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement