257947-31-2Relevant academic research and scientific papers
A highly efficient and practical new PEG-bound bi-cinchona alkaloid ligand for the catalytic asymmetric aminohydroxylation of alkenes
Yang, Xi-Wen,Liu, Han-Quan,Xu, Ming-Hua,Lin, Guo-Qiang
, p. 1915 - 1918 (2004)
A new recyclable PEG-bound bi-cinchona alkaloid ligand has been developed for homogeneous catalytic asymmetric aminohydroxylation; it can be easily recovered by precipitation and reused more than five times without any significant loss in its catalytic efficiency.
Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
-
, (2008/06/13)
The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro 2-hydroxy-3-amino-3-phenylpropionamide by diastereomeric crystalliz
