25797-01-7Relevant academic research and scientific papers
A Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts
Yan, Qiao,Gin, Emma,Banwell, Martin G.,Willis, Anthony C.,Carr, Paul D.
, p. 4328 - 4335 (2017/04/28)
A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-tetrahydro-α-carboline that is itself readily aromatized to give α-carboline (1).
Rapid and efficient microwave-assisted synthesis of 4-, 5-, 6- and 7-azaindoles
Lachance, Nicolas,April, Myriam,Joly, Marc-Andre
, p. 2571 - 2577 (2007/10/03)
Under microwave irradiation conditions, the imines/enamines formed between aminopyridines and ketones are converted in moderate to good yields to the corresponding 4-, 5-, 6- or 7-azaindoles via the Hegedus-Mori-Heck reaction (intramolecular Heck reaction
SRN1 REACTION. SYNTHETIC APPLICATION TO 4-AZAINDOLES
Fontan, Rafael,Galvez, Carmen,Viladoms, Pere
, p. 1473 - 1474 (2007/10/02)
A new synthetic method for 4-azaindoles, based on nucleophilic heteroaromatic substitution via a radical intermediate (SRN1 reaction) is described.
SUBSTITUTION NUCLEOPHILE AROMATIQUE RADICALAIRE (1) SYNTHESE DIRECTE DE 4-AZA-INDOLES DANS DES CONDITIONS NON ACIDES ET DOUCES
Beugelmans, Rene,Boudet, Bernard,Quintero, Leticia
, p. 1943 - 1944 (2007/10/02)
A one pot synthesis of the 4-Aza-indole skeleton starting from 2-chloro-4-amino pyridine and based upon the SRN1 reaction is reported.
