2580-60-1

Basic information

• Product Name: oxybisacetohydrazide
• Synonyms: oxybisacetohydrazide;Diglycolic dihydrazide;2,2'-Oxybisacetic acid dihydrazide
• CAS NO: 2580-60-1
• Molecular Formula: C₄H₁₀N₄O₃
• Molecular Weight: 162.1472
• EINECS: 219-945-7
• Mol File: 2580-60-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 533.5°Cat760mmHg
• Flash Point: 276.5°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 1.85E-11mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: oxybisacetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: oxybisacetohydrazide(2580-60-1)
• EPA Substance Registry System: oxybisacetohydrazide(2580-60-1)

Safety Data

• Hazardous Substances Data: 2580-60-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H10N4O3/c5-7-3(9)1-11-2-4(10)8-6/h1-2,5-6H2,(H,7,9)(H,8,10)

Upstream product

• 7040-23-5 dimethyl diglycolate 

Relevant articles and documents

Design and Development of Mycobacterium tuberculosis Lysine ε-Aminotransferase Inhibitors for Latent Tuberculosis Infection

Lysine ε-aminotransferase (LAT) is a protein involved in lysine catabolism, and it plays a significant role during the persistent/latent phase of Mycobacterium tuberculosis (MTB), as observed by its up-regulation by ~40-fold during this stage. We have used the crystal structure of MTB LAT in external aldimine form in complex with its substrate lysine as a template to design and identify seven lead compounds with IC50 ranging from 18.06 to > 90 μm. We have synthesized 21 compounds based on the identified lead, and compound 21 [2,2′-oxybis(N′-(4-fluorobenzylidene)acetohydrazide)] was found to be the most active with MTB LAT IC50 of 0.81 ± 0.03 μm. Compound 21 also showed a 2.3 log reduction in the nutrient-starved MTB model and was more potent than standard isoniazid and rifampicin at the same dose level of 10 μg/mL.