25811-48-7Relevant academic research and scientific papers
Glycolic ester derivative and its use
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Paragraph 0066; 0067; 0068; 0069; 0070, (2017/06/29)
The invention relates to hydroxyacetic acid ester derivatives and use thereof and particularly relates to compounds shown in the formula I, or pharmaceutically acceptable salts, esters, solvates and prodrugs of the compounds, wherein R1 and R2 are respectively selected from phenyl, cyclohexyl, cyclopentyl and thienyl and are optionally substituted by 1-3 groups of hydroxy, halogen, trifluoromethyl, trifluoromethoxy, amino, carboxy, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)alkenyl, (C1- C4)alkynyl, N-(C1-C4)alkylamino. The invention further relates to a method for preparing the compounds, pharmaceutical compositions containing the compounds and pharmaceutical use of the compounds. The compound provided by the invention can be used for treating respiratory system diseases including but not limited to asthma, chronic obstructive pulmonary disease and the like.
Biomimetic investigations of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate
Froehlich,Pietzyk,Smolinka,Goeber
, p. 745 - 747 (2007/10/03)
The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)-β-tetrasulfonat oporphyrin chloride (MnTPFPS4PCl)/imidazole/hydrogen peroxide in aqueous solution at pH 7-8 affords unchanged 1 and 2 and numerous metabolites, which are products of fission of the ester bond, of O-dealkylation, decarboxylation, N-demethylation, and oxidation of the tertiary amine function. In contrast to the nonaqueous system with the catalyst manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl) aromatic hydroxylation is not observed. This result shows conformity with the studies of metabolism in men.
Biomimetic oxidation of propiverinhydrochloride and 1-methyl-4-piperidyl benzilate
Frohlich,Pietzyk,Gober
, p. 736 - 740 (2007/10/03)
The reaction of propiverinhydrochloride (1) and 1-methyl-4-piperidyl benzilate (2) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/pyridine/hydrogen peroxide affords unchanged 1 and 2 and 15 potential metabolites, which were isolated and identified. These compounds are products of cleavage of the ester bond, of O-dealkylation, aromatic oxidation, respectively of decarboxylation, demethylation, and N-oxidation. Products were identified by TLC, UV, and MS in comparison with authentic samples. Thereby we found a nearly conformity with rat metabolism.
