258278-64-7 Usage
Description
SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 μM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.
Check Digit Verification of cas no
The CAS Registry Mumber 258278-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,8,2,7 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 258278-64:
(8*2)+(7*5)+(6*8)+(5*2)+(4*7)+(3*8)+(2*6)+(1*4)=177
177 % 10 = 7
So 258278-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO6S/c1-22-15(18)13-4-2-3-5-14(13)24-16(19)12-8-6-11(7-9-12)10-23-17(20)21/h2-9H,10H2,1H3
258278-64-7Relevant articles and documents
No-donors, part 3: Nitrooxyacylated thiosalicylates and salicylates - Synthesis and biological activities
Endres, Stefan,Hacker, Andreas,Noack, Eike,Kojda, Georg,Lehmann, Jochen
, p. 895 - 901 (2007/10/03)
Organic nitrates release nitric oxide when incubated with thiosalicylic acid. S-Nitrooxyacylated esters and amides of thiosalicylic acid, together with the corresponding salicylates, were synthesized in order to perform a first in vitro evaluation of these new nitrate-thiol-hybrid prodrugs. These prodrugs might release NO in vivo after biotransformation without the use of endogenous reductives. None of these prodrugs released NO spontaneously when dissolved in buffer solution, but they did activate soluble guanylyl cyclase and induced vasodilatation of phenylephrine-pretreated male Wistar rat aorta in a potency range between that of isosorbiddinitrate and glycerole trinitrate.
