258286-06-5Relevant academic research and scientific papers
Synthesis of enantiomerically pure cis-2,4-disubstituted piperidines: Extension of chiral homoenolate alkylations toward the preparation of nitrogen heterocycles
Dwyer, Michael P.,Lamar, Jason E.,Meyers
, p. 8965 - 8968 (1999)
Enantiomerically pure cis-2,4-disubstituted piperidines were synthesized from chiral thiolactam 2 in six steps via a highly diastereoselective homoenolate alkylation which set the stereochemistry at the C4 carbon. In addition, two cleavage methods were used to cleave the lactam to the desired piperidines with a high level of diastereoselection at the newly created C2 stereocenter.
