258286-29-2Relevant academic research and scientific papers
Synthesis of capsular polysaccharide oligomers of Salmonella typhi, bacteria originated from typhoid fever
Shi-Shun, Lian Kiow,Mallet, Jean-Maurice,Moreau, Monique,Sina?, Pierre
, p. 14043 - 14068 (2007/10/03)
The highly antigenic capsular polysaccharide of Salmonella typhi is a polysaccharide made out of N-acetyl D-galactosaminuronic acid units connected together through an α(1→4) linkage. Most of the hydroxyl groups at C-3 are acetylated. In order to determine the minimal size of fragments required for eliciting a significant immunological response, the corresponding di, tri, tetra and hexasaccharides have been chemically synthesized. The strategy is based on the use of anomeric S-xanthates of 2-azido-2-deoxy-D- galactopyranosyl derivatives as glycosyl donors. It has been shown that tetra and hexasaccharides are able to inhibit antibody binding by native polysaccharide.
