258286-95-2

Upstream product

• 231960-72-8 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one 
• 502-42-1 cycloheptanone 
• 100-58-3 phenylmagnesium bromide 
• 20662-53-7 4-(2-keto-1-benzimidazolinyl)piperidine 

Downstream Products

• 352541-75-4 t-butyl 3-{1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1H-benzimidazol-2-yl}-3,8-diazabicyclo[3.2.1]octane-8-carboxylate 

Relevant academic research and scientific papers

Scalable preparation of benzimidazole compounds

The preparation of benzimidazole compound 7, an ORL-1 agonist, is described. The four-step procedure gave the compound 7 in 29% overall yield. Copyright Taylor & Francis Group, LLC.

Benzimidazole compounds as ORL1-receptor agonists

A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is unsubstituted, mono-, di- or tri-substituted (C3-C11)cycloalkyl or (C3-C11)cycloalkenyl or the like, A is unsubs

2-substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists

A compound of the formula: STR1or a pharmaceutically acceptable salt thereof, wherein R is unsubstituted, mono-, di- or tri-substituted (C 3 -C 11)cycloalkyl or (C 3 -C 11)cycloalkenyl or the like, A is unsubstituted (C 1 -C 7)alkyl or (C 2 -C 5 )alkenyl,