258336-47-9Relevant academic research and scientific papers
Facile solid-phase construction of indole derivatives based on a traceless, activating sulfonyl linker
Zhang, Han-Cheng,Ye, Hong,Moretto, Alessandro F.,Brumfield, Kimberly K.,Maryanoff, Bruce E.
, p. 89 - 92 (2000)
(formula presented) Palladium-mediated coupling/intramolecular indole cyclization of terminal alkynes with resin 8, followed by cleavage of the sulfonamide linkage, were executed under mild conditions to provide diverse indoles 10 in excellent yield and purity. This chemistry benefits from a dual-activation process that derives from use of a traceless N-sulfonyl linker. Also, direct mercuration of 9 (X = H, R = 4-Me-C6H4), followed by palladium-mediated coupling with methyl acrylate, efficiently provided 3-functionalized product 12.
Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells
Kaufmann, Doris,Pojarova, Michaela,Vogel, Susanne,Liebl, Renate,Gastpar, Robert,Gross, Dietmar,Nishino, Tsuyuki,Pfaller, Tobias,von Angerer, Erwin
, p. 5122 - 5136 (2008/03/27)
Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231
