25834-24-6Relevant academic research and scientific papers
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: Synthesis of clofibrate analogues
Perrone, Maria Grazia,Santandrea, Ernesto,Di Nunno, Leonardo,Scilimati, Antonio,Tortorella, Vincenzo,Capitelli, Francesco,Bertolasi, Valerio
, p. 783 - 792 (2007/10/03)
Clofibrate is a well-known peroxisome proliferator-activated receptor-α (PPARα) agonist, used in the treatment of hyperlipaemias and atherosclerosis and to prevent heart failure. Herein, the preparation of the four enantiomerically pure stereoisomers of e
The synthesis of solvent-free glycidic esters from diazoesters and carbonyl compounds catalysed by lanthanide trifiates
Curini, Massimo,Epifano, Francesco,Marcotullio, Maria Carla,Rosati, Ornelio
, p. 1562 - 1565 (2007/10/03)
The results of the reaction between ethyl diazoacetate and carbonyl compounds catalysed by lanthanide triflates are described. Aldehydes, and α-unsubstituted and α-monosubstituted cyclohexanones react to give the selective formation of α,β-epoxy esters (g
Practical synthesis of optically pure methyl (2R,3S)-2,3-epoxybutanoate via microbial asymmetric reduction of α-chloroacetoacetate
Akita,Todoroki,Endo,Ikari,Oishi
, p. 513 - 516 (2007/10/02)
Asymmetric reduction of ethyl α-chloroacetoacetate (3) with Baker's yeast followed by treatment with sodium ethoxide afforded a mixture of ethyl (2R,3S)-(8) and (2S,3S)-2,3-epoxybutanoate (9) (8/9, 85:15), which could be converted into the optically pure methyl (2R,3S)-2,3-epoxybutanoate (25) via one recrystallization of the brucine salt of the diastereomeric mixture of the corresponding epoxy acid.
Synthesis and Reactions of 3-Hydroxy-2-nosyloxy Esters Produced by the Stereoselective Reduction of 2-Nosyloxy-3-keto Esters
Hoffman, Robert V.,Kim, Hwa-Ok
, p. 6759 - 6764 (2007/10/02)
The reduction of 2-nosyloxy-3-keto esters is an effective method for the preparation of 3-hydroxy-2-nosyloxy esters.The reduction is stereoselective for the syn isomer.The anti isomer can be produced as the major product by the addition of p-nitrobenzenesulfonyl peroxide to ketene bis-silyl acetal derivatives of 3-hydroxy esters.The diastereomers are separable chromatographically and can be converted stereospecifically to glycidic esters and 2-azido-3-hydroxy esters.As such they appear to have excellent potential as versatile synthetic intermediates for the synthesis of 1,2,3-trifunctional substances.
