258346-53-1

Upstream product

• 258346-55-3 3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoic acid 

Downstream Products

• 784149-79-7 3-(5-methyl-2-phenyl-oxazol-4-yl)-propionaldehyde 
• 475480-64-9 [rac]-2-ethoxy-3-{2-methyl-4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propoxy]-phenyl}-propionic acid 
• 501031-63-6 4-(3-Bromo-propyl)-5-methyl-2-phenyl-oxazole 
• 652980-36-4 4-(3-chloropropyl)-5-methyl-2-phenyl-1,3-oxazole 
• 103788-31-4 5-{4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propoxy]-benzyl}-thiazolidine-2,4-dione 
• 103789-30-6 2-Imino-5-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propoxy]-benzyl}-thiazolidin-4-one 
• 141399-43-1 4-[3-(5-Methyl-2-phenyl-oxazol-4-yl)-propoxy]-phenylamine 
• 103789-27-1 5-Methyl-4-[3-(4-nitro-phenoxy)-propyl]-2-phenyl-oxazole 

Relevant academic research and scientific papers

Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

A new series of 1,3-dioxane-2-carboxylic acid derivatives was synthesized and evaluated for agonist activity at human peroxisome proliferator-activated receptor (PPAR) subtypes. Structure-activity relationship studies led to the identification of 2-methyl-c-5-[4-(5-methyl-2-phenyl-1,3-oxazol-4-yl)butyl]-1,3-dioxane-r-2-carboxylic acid 4b as a potent PPARα agonist with high subtype selectivity at human receptor subtypes. This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-Ay mice.

INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS

This invention relates to novel indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives whice are useful in the treatment of diseases such sa diabetes, diabetes-related disorders, obesity, hyperlipidemia, and cardiovascular diseases. The invention also relates to intermediates useful in preparation of said carboxylic derivatives and to methods of preparation.

ANTIDIABETIC AGENTS

Compounds of formula I: wherein X, Y, B, E, J, K, L, Z, and R9-R12 have any of the meanings described herein, their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as