258348-41-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 258348-37-7 Benzoic acid (2R,5R)-5-(3-benzoyl-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-[1,3]oxathiolan-2-ylmethyl ester 
• 258348-35-5 Benzoic acid (2R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-2-ylmethyl ester 

Downstream Products

• 258348-43-5 1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-5-ylmethyl]-5-fluoro-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Diastereoselective synthesis of L-(+)-homolamivudine

L-homolamivudine (2a, (2R,5R)-(+)-cis-5-(1-cytosinylmethyl)-2-hydroxymethyl-1,3-oxathiolane) and its 5-fluoro congener (2b, L-homoFTC) have been prepared from (R)-glycidol by diastereoselective synthesis. Enantioselectivity resulted from stereoselective cyclothioacetalization that preferentially gave the (2R,5R)-cis-2,5-disubstituted-1,3-oxathiolane (5), cis/trans = 5.7.