25845-92-5Relevant academic research and scientific papers
Synthesis and cytotoxicity of (3β)-3-acetyloxy-5(6)-androsten-7-one oxime and 3,5(6)-androstadien-7-one oxime
Yao, Juan,Ye, Weijian,Liu, Jinliang,Liu, Juanjuan,Wang, Cunde
, p. 1839 - 1843 (2014/05/06)
(3β)-3-Acetyloxy-5(6)-androsten-7-one oxime and 3,5(6)-androstadien-7- one oxime were synthesized and their in vitro cytotoxic activities against human epidermoid carcinoma cell line KB, human cervical carcinoma cell line HeLa, human gastric carcinoma cell line MKN-28, and human breast carcinoma cell line MCF-7 were evaluated. The compound (3b)-3-acetyloxy-5(6)-androsten-7-one oxime exhibited significant growth inhibitory properties against cell lines tested and afforded IC 50 value 26.0 ± 1.6, 12.8 ± 1.0, 18.1 ± 0.2, 10.2 ± 1.2 lM for KB, HeLa, MKN-28, and MCF-7, respectively. Springer Science+Business Media 2013.
Allylic and benzylic oxidation using cobalt(II) alkyl phosphonate modified silica
Jurado-Gonzalez, Magdalena,Sullivan, Alice C.,Wilson, John R. H.
, p. 4283 - 4286 (2007/10/03)
The allylic and benzylic oxidation of a range of substrates proceeds in good yield using catalytic quantities of cobalt(II) alkyl phosphonate modified silica and tert-butyl hydroperoxide.
The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using homogeneous and heterogeneous cobalt acetate
Salvador,Clark
, p. 33 - 34 (2007/10/03)
Cobalt acetate is an effective catalyst for the selective allylic oxidation of unsaturated steroids using tert-butyl hydroperoxide especially when used in a supported form when it can be easily recovered and reused.
Photochemical Behavior of Δ4-3-Oxo, Δ5-7-Oxo, and Δ1-3-Oxo Steroids in Concentrated Acid Solution
Lupon, Pilar,Canals, Francesc,Iglesias, Arsenio,Ferrer, Joan C.,Palomer, Albert,et al.
, p. 2193 - 2198 (2007/10/02)
Irradiation with UV light of 5α-androst-1-en-3-one (9) in concentrated sulfuric acid leads to 15 and 16; similarly 4a-methyl-4a,5,6,7,8,8a-hexahydronaphthalen-2(1H)-one (10) gives 17 and 18.The formation of the four products is rationalized in terms of a photochemically induced 1,2-alkyl shift to the positively charged positions of the starting carbenium ions.On the other hand, irradiation under the same conditions of 4, 8, 7, and 11 yields, quantitatively, unchanged starting material, while the analogous bicyclic compound Δ1,9-10-methyl-2-octalone (1) has been reported to yield photorearrangement products.The lack of reactivity of 7 and 11 can be explained according to the proposed mechanism for the photorearrangement of 1.In the case of 4 and 8, the presence of the steroid rings C and D prevents the photorearrangement, but the mechanistic explanation of this effect cannot be determined from the present experimental data.
The Woodward-Prevost Reaction with 5α-Androst-7-ene
Cambie, Richard C.,Craw, Peter A.,Hughes, Ronald J.,Rutledge, Peter S.,Woodgate, Paul D.
, p. 2111 - 2130 (2007/10/02)
5α-Androst-7-ene (8) has been prepared from 3β-hydroxyandrost-5-en-17-one by a route which is superior to the usual procedure for making steroidal 7-enes.The products from reaction of 5α-androst-7-ene under Woodward-Prevost conditions are 5α-androsta-7,9(
