258497-21-1

Basic information

• Product Name: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLATE;6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID;6-N-BOC-AMINOPICOLINIC ACID;2-PYRIDINECARBOXYLIC ACID, 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-;6-((tert-Butoxycarbonyl)aMino)picolinic acid;6-[[(1,1-dimethylethoxy)carbonyl]amino]-2-Pyridinecarboxylic acid;6-BOC-AMINO-PYRIDINE-2-CARBOXYLIC ACID;6-[(tert-Butoxycarbonyl)amino]-2-pyridinecarboxylic acid
• CAS NO: 258497-21-1
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.24
• Product Categories: pharmacetical
• Mol File: 258497-21-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 360.385 °C at 760 mmHg
• Flash Point: 171.755 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• PKA: 1.07±0.50(Predicted)
• CAS DataBase Reference: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(258497-21-1)
• EPA Substance Registry System: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(258497-21-1)

Safety Data

• Hazardous Substances Data: 258497-21-1(Hazardous Substances Data)

Usage

General Description

6-Tert-Butoxycarbonylamino-pyridine-2-carboxylic acid is a chemical compound with the molecular formula C14H16N2O4. It is a derivative of pyridine carboxylic acid and contains a tert-butoxycarbonyl functional group. 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its structure and properties make it useful in the development of new drugs and biological compounds. Furthermore, it has potential applications in the field of medicinal chemistry and drug discovery, making it an important chemical for research and development purposes.

InChI:InChI=1/C11H14N2O4/c1-11(2,3)17-10(16)13-8-6-4-5-7(12-8)9(14)15/h4-6H,1-3H3,(H,14,15)(H,12,13,16)

Upstream product

• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 69142-64-9 ethyl 6-aminopicolinate 
• 408368-74-1 tert-butyl 6-{[(4-nitrobenzyl)amino]carbonyl}-2-pyridinylcarbamate 
• 259533-24-9 3-[4-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-[1,2,3]thiadiazol-5-ylsulfanyl]-7-[2-(6-tert-butoxycarbonylamino-pyridin-2-yl)-2-trityloxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 258497-27-7 (6-tert-butoxycarbonylamino-pyridin-2-yl)-trityloxyimino-acetic acid methyl ester 
• 258497-18-6 (Z)-2-(2-tert-butoxycarbonylaminopyrid-6-yl)-2-(triphenylmethoxyimino)acetic acid 
• 258497-48-2 methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate 

Relevant articles and documents

7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof

The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1is selected from the group consisting of hydrogen and —C(O)CH(NH2)CH3and R′2is selected from the group consisting of hydrogen and an acyl group that is cleaved by an enzyme found in mammals, with the proviso that, when either R′1or R′2is hydrogen, the other is not. A, B, L, G, E, and J are each independently nitrogen or carbon such that the respective rings are selected from the group consisting of provided that the group —CH2—S—CH2CH2NHR′2is attached only to a carbon atom of said heterocyclic group, and Q is selected from the group consisting of nitrogen and —CX, wherein X is selected from the group consisting of hydrogen and chlorine.

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position

Incorporation of a basic aminopyridine into the C-7 position of 3-(amine-substituted arylthio)-3-norcephalosporins, as in 3, afforded high potency against MRSA and acceptable solubility for intravenous administration.

Cephalosporin antibiotics

The present invention includes novel compounds of formula where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R99 is selected from the group consisting of sulfur, SO, S02, NH, N-alkyl, oxygen, C=C (cis or trans), and C 3BOND C, and R12 is NR13R14, The invention also includes the pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to beta -lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.