258516-82-4

Basic information

• Product Name: 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE
• Synonyms: 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE;Fospropofol disodiuM I
• CAS NO: 258516-82-4
• Molecular Formula: C₁₃H₁₉ClO
• Molecular Weight: 226.74236
• Mol File: 258516-82-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 300.6°C at 760 mmHg
• Flash Point: 137.6°C
• Appearance: /
• Density: 1.007
• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE(258516-82-4)
• EPA Substance Registry System: 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE(258516-82-4)

Safety Data

• Hazardous Substances Data: 258516-82-4(Hazardous Substances Data)

Usage

General Description

2-Chloromethoxy-1,3-diisopropyl-benzene is a chemical compound with the molecular formula C13H21ClO. It is a colorless to light yellow liquid with a faint, sweet odor. 2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE is used in the production of fragrances, flavors, and pharmaceuticals. It is also used as an intermediate in the synthesis of various organic compounds. Due to its chemical properties, it is important to handle this compound with caution, as it may cause irritation to the skin, eyes, and respiratory system. Additionally, it is important to follow proper safety protocols when handling and storing this chemical to prevent any potential health hazards.

InChI:InChI=1/C13H19ClO/c1-9(2)11-6-5-7-12(10(3)4)13(11)15-8-14/h5-7,9-10H,8H2,1-4H3

Upstream product

• 2944-52-7 2,6-diisopropyl anisole 
• 2078-54-8 2,6-diisopropylphenol 
• 593-71-5 Chloroiodomethane 
• 74-97-5 chlorobromomethane 

Downstream Products

• 258516-89-1 fospropofol 

Relevant articles and documents

Synthesis method and application of propofol sodium and intermediate thereof

The method comprises an intermediate B and an intermediate C, and, the application of the phosphorus propofol sodium prepared by the synthesis method in an animal anesthetic sedative. The phosphorus propofol sodium synthesis method provided by the invention avoids the use of highly toxic reagent chlorobromomethane and is high in safety. The prepared propofol intermediate reaction condition is mild, the operation is simple and convenient, the quality yield is ＞ 97%, and the propofol prodrug synthesized by the synthetic method provided by the invention can generate the same clinical effect as the commercially available propofol emulsion injection.

Monodisperse oligoethylene glycols modified Propofol prodrugs

The low water solubility of Propofol resulted in complicated formulation and adverse effects during its clinical application. To improve its water solubility and maintain its anesthetic effects, Propofol prodrugs with monodisperse oligoethylene glycols as solubility enhancer were designed and synthesized. Monodisperse oligoethylene glycols enable the concise manipulation of water solubility, biocompatibility and anesthetic effects. Through the physicochemical and biological assay, a few water soluble prodrugs of Propofol were identified as promising anesthetic to overcome the drawbacks associated with Propofol.

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

A novel ethyl dioxy phosphate prodrug of propofol (3) was synthesized and characterized in vitro and in vivo as safer alternative for phosphonooxymethyl prodrugs. The synthesis of 3 was achieved via vinyl and 1-chloroethyl ether intermediates, followed by