258516-82-4

Usage

Uses

Used in Fragrance and Flavor Industry:
2-Chloromethoxy-1,3-diisopropyl-benzene is used as a raw material for the production of fragrances and flavors, contributing to the development of unique scents and tastes in various consumer products.
Used in Pharmaceutical Industry:
2-CHLOROMETHOXY-1,3-DIISOPROPYL-BENZENE is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs and medications.
Used in Organic Synthesis:
2-Chloromethoxy-1,3-diisopropyl-benzene is employed as an intermediate in the synthesis of various organic compounds, facilitating the creation of a wide range of chemical products.
Safety Precautions:
Due to its potential to cause irritation to the skin, eyes, and respiratory system, it is essential to handle 2-chloromethoxy-1,3-diisopropyl-benzene with caution. Adhering to proper safety protocols during handling and storage is crucial to prevent any potential health hazards.

InChI:InChI=1/C13H19ClO/c1-9(2)11-6-5-7-12(10(3)4)13(11)15-8-14/h5-7,9-10H,8H2,1-4H3

Upstream product

• 74-97-5 chlorobromomethane 
• 2078-54-8 2,6-diisopropylphenol 
• 593-71-5 Chloroiodomethane 
• 2944-52-7 2,6-diisopropyl anisole 

Downstream Products

• 258516-89-1 fospropofol 

Relevant academic research and scientific papers

Synthesis method and application of propofol sodium and intermediate thereof

The method comprises an intermediate B and an intermediate C, and, the application of the phosphorus propofol sodium prepared by the synthesis method in an animal anesthetic sedative. The phosphorus propofol sodium synthesis method provided by the invention avoids the use of highly toxic reagent chlorobromomethane and is high in safety. The prepared propofol intermediate reaction condition is mild, the operation is simple and convenient, the quality yield is ＞ 97%, and the propofol prodrug synthesized by the synthetic method provided by the invention can generate the same clinical effect as the commercially available propofol emulsion injection.

Phosphoric acid derivative as well as preparation method and application thereof

The invention relates to a compound of a general formula (I), a stereoisomer or pharmaceutically acceptable salt of the compound and application of the compound in medicines. The structure of the compound of the general formula (I) is Q-L-R, and the groups of the compound are defined in the specification.

Monodisperse oligoethylene glycols modified Propofol prodrugs

The low water solubility of Propofol resulted in complicated formulation and adverse effects during its clinical application. To improve its water solubility and maintain its anesthetic effects, Propofol prodrugs with monodisperse oligoethylene glycols as solubility enhancer were designed and synthesized. Monodisperse oligoethylene glycols enable the concise manipulation of water solubility, biocompatibility and anesthetic effects. Through the physicochemical and biological assay, a few water soluble prodrugs of Propofol were identified as promising anesthetic to overcome the drawbacks associated with Propofol.

Synthesis and characterization of novel quick-release propofol prodrug via lactonization

The water-soluble derivatives of propofol have gained attention as a method to increase solubility of propofol. According to the principle of lactonization, the lead compound HX0969 was synthesized first and then the pharmacological features of HX0969 wer

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

A novel ethyl dioxy phosphate prodrug of propofol (3) was synthesized and characterized in vitro and in vivo as safer alternative for phosphonooxymethyl prodrugs. The synthesis of 3 was achieved via vinyl and 1-chloroethyl ether intermediates, followed by