Welcome to LookChem.com Sign In|Join Free

CAS

  • or

25875-50-7

Post Buying Request

25875-50-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

25875-50-7 Usage

Description

Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Chemical Properties

white or slightly yellow crystalline powder, odorless, slightly bitter taste. Very slightly soluble in ether and water, easily soluble in dilute acid or dilute alkali solution, the color gradually darkens when exposed to light.

Uses

Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Preparation

thiosemicarbazide was formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylation with dimethyl sulfate and hydrazinolysis to give N.N'-diaminoguanidine sulfate. Then replaced with calcium chloride to N.N'-diaminoguanidine hydrochloride. Finally, it was condensed with p-chlorobenzaldehyde in ethanol again to produce Robenidine hydrochloride with 94% yield.

Antimicrobial activity

Robenidine hydrochloride activity against Eimeria species results from a dual action exerted upon different stages of the parasite as it develops in the intestinal mucosa (Ryley and Wilson, 1971). Initially it acts as a coccidiostat and arrests the development of the first schizont generation. Secondly, robenidine hydrochloride is coccidiocidal, killing the second generation of schizonts and possibly the merozoites. An additional effect against the sexual stage of coccidia development has been observed as well. Robenidine hydrochloride has been shown to be an inhibitor of oxidative phosphorylation (Wong et al., 1972) and is reported to affect the protein metabolism and some other metabolic process of coccidia (Lee and Millard, 1972).

Biological Activity

Robenidine Hydrochloride is an anticoccidial agent mainly for poultry which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. IC50 & Target: MIC50: 8.1 μM (MRSA), 4.7 μM (VRE).In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine.

Check Digit Verification of cas no

The CAS Registry Mumber 25875-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,8,7 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25875-50:
(7*2)+(6*5)+(5*8)+(4*7)+(3*5)+(2*5)+(1*0)=137
137 % 10 = 7
So 25875-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;

25875-50-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma-Aldrich

  • (33979)  Robenidinehydrochloride  VETRANAL, analytical standard

  • 25875-50-7

  • 33979-100MG-R

  • 780.39CNY

  • Detail

25875-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Robenidine Hydrochloride

1.2 Other means of identification

Product number -
Other names Robenidine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25875-50-7 SDS

25875-50-7Synthetic route

1,3-diaminoguanidine hydrochloride
36062-19-8

1,3-diaminoguanidine hydrochloride

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 1h; pH=1.5; pH-value; Temperature;98.82%
In ethanol for 16h; Reflux;
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

2-(isocyanatomethyl)furan
71189-15-6

2-(isocyanatomethyl)furan

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;84%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

C23H20Cl2N6O*ClH

C23H20Cl2N6O*ClH

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;61%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

ethyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

ethyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;42%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

isobutyl chloroformate
543-27-1

isobutyl chloroformate

isobutyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

isobutyl 2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;39%
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

ethyl isocyanate
109-90-0

ethyl isocyanate

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-ethylhydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-ethylhydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;33%
Hexyl isocyanate
2525-62-4

Hexyl isocyanate

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride
25875-50-7

2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-hexylhydrazine-1-carboxamide

2-((E)-4-chlorobenzylidene)-1-((E)-N'-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-hexylhydrazine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 2.5h; Reflux;16%

25875-50-7Downstream Products

25875-50-7Relevant articles and documents

Preparation method of robenidine hydrochloride

-

Paragraph 0019; 0020, (2016/10/07)

The invention discloses a preparation method of robenidine hydrochloride. 1, 3-diaminoguanidine hydrochloride as a raw material, methanol as a solvent and p-chlorobenzaldehyde undergoes a condensation reaction to produce the robenidine hydrochloride. The preparation method comprises adding 1, 3-diaminoguanidine hydrochloride and methanol into a reactor, heating the raw materials to a temperature of 45-55 DEG C until the reactants are completely dissolved, adjusting pH of the solution to 1.5-2 by hydrochloric acid methanol, dropwisely adding a p-chlorobenzaldehyde-methanol solution into the reaction solution at a temperature of 45-55 DEG C at a stirring speed of 80r/min, after dropwise addition, carrying out a reflux reaction process for 1-2h, carrying out distillation to recover methanol, adding water into the reaction product, carrying out beating, and carrying out filtration, water washing and drying to obtain robenidine hydrochloride. The condensation reaction under waterless conditions is conducive to smooth reaction and greatly improves a reaction yield. The solvent can be recovered and recycled, product content is high, further purification is avoided and high economical efficiency and environmental friendliness are obtained.

Purification of robenidine hydrochloride

-

, (2008/06/13)

A superior grade of 1,3-bis(4-chlorobenzylideneamino)-guanidine hydrochloride is obtained by dispersing crude material in a suitable solvent, slowly adding to the dispersion an amount of base at least equivalent to the number of moles of 1,2,3-tris(4-chlorobenzylideneamino)guanidine hydrochloride present in said crude 1,3-bis(4-chlorobenzylideneamino)guanidine hydrochloride, separating the purified 1,3-bis(4-chlorobenzylideneamino)guandidine hydrochloride therefrom, and washing and drying the same.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 25875-50-7