25877-35-4

Usage

Nitro-substituted benzotriazole derivative

A compound in which a nitro group (-NO2) has replaced a hydrogen atom on the benzotriazole (a 5-membered ring system with two nitrogen atoms) structure.

Corrosion inhibitor

1-Methyl-6-nitro-1H-benzotriazole is commonly used to prevent or slow down the corrosion of metals, particularly steel and aluminum.

Carboxylate-based corrosion inhibitors

The compound is particularly effective in carboxylate-based systems, which are chemical compounds containing a carboxyl group (-COOH) that can form a salt with metal ions, providing protection against corrosion.

Intermediate in synthesis

1-Methyl-6-nitro-1H-benzotriazole is used as a starting material or intermediate in the production of other chemical compounds, such as pharmaceuticals, dyes, and pigments.

Harmful if swallowed, inhaled, or in contact with skin

The compound poses a health risk if it is ingested, breathed in, or comes into contact with the skin due to its toxic nature.

Causes irritation to respiratory system and skin

Exposure to 1-Methyl-6-nitro-1H-benzotriazole may lead to inflammation and discomfort in the respiratory system and on the skin.

Handling precautions

To minimize the risks associated with 1-Methyl-6-nitro-1H-benzotriazole, it should be handled with extreme caution, following all relevant safety regulations and guidelines.

InChI:InChI=1/C7H6N4O2/c1-10-7-4-5(11(12)13)2-3-6(7)8-9-10/h2-4H,1H3

Upstream product

• 2338-12-7 5-nitrobenzotriazole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 95576-84-4 N₂-methyl-4-nitrobenzene-1,2-diamine 

Downstream Products

• 127280-81-3 1-Methyl-6-nitro-7-(phenylsulfonylmethyl)benzotriazol 
• 26861-23-4 6-amino-1-methyl-1H-benzotriazole 

Relevant academic research and scientific papers

QUINAZOLINE COMPOUNDS USEFUL AS M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to compounds of Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R7, R8, R9, R11, n and p are defined herein. The compounds of Formula (I) are M1 receptor positive allosteric modulators that are useful in the treatment of diseases in which the M1 receptor is involved, including Alzheimer's disease, schizophrenia, pain and sleep disorders. The invention also relates to pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier, and to methods of using the compounds of Formula (I) in the treatment of diseases mediated by the M1 receptor.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS

Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and / or systemic lupus

Reactions of chloride salts of 7-amino-9-ethylguanine and 1-amino-3- methylbenzimidazoles with lead(IV) acetate: Formation of 8-aza-9-ethylguanine and 1-methyl-1H-benzotriazoles

Reaction of 7-amino-9-ethylguaninium chloride with lead(IV) acetate (LTA) in MeOH yielded 8-aza-9-ethylguanine. Similarly, the reaction of 1- amino-3-methylbenzimidazolium chloride or its substituted derivatives (6- methyl,5,6-dimethyl and 5-nitro) with LTA gave the corresponding 1-methyl- 1H-benzotriazole (or 1-methyl-2-azabenzimidazole) derivatives along with N- methylformanilide derivatives.

Synthesis, antimicrobial data and correlation analysis in a set of 2-alkyl-5-amidobenzotriazoles

A set of 2-alkyl-5-amidobenzotriazoles has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k') have been experimentally determined. The in vitro antimicrobial activity against Gram-positive, Gram-negat

THE CHEMISTRY OF N-SUBSTITUTED BENZOTRIAZOLES. PART 18. A STUDY OF THE INFLUENCE OF STRUCTURE ON THE 1- TO 2-(N,N-DIALKYLAMINOALKYL)BENZOTRIAZOLE EQUILIBRIUM

The equilibrium constants, the associated free energies for the equilibria, and the free energies of activation for the isomerization process of a series of 1- and 2-(N,N-dialkylaminoalkyl)benzotriazoles of types (8)-(11) were calculated from the variable temperature 1H-nmr spectra.Trends in the magnitudes of these energies and equilibrium constants are correlated with the molecular structure.