258820-07-4

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 219692-15-6 (3,5-dibromo-4-(5-isopropyl-4-methoxy-phenoxy)-phenyl)-acetic acid methyl ester 

Downstream Products

• 258819-64-6 (4-(2-(3-Bromo-benzoyl)-5-isopropyl-4-methoxy-phenoxy)-3,5-dibromo-phenyl)-acetic Acid 

Relevant academic research and scientific papers

Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders

Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): in which R1is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, or cyano, or a pharmaceutically acceptable salt thereof. R2and R3are the same or different, and are hydrogen, halogen, alkyl of 1 to 4 carbons, or cycloalkyl of 3 to 5 carbons, at least one of R2and R3being other than hydrogen. X is carbonyl or methylene. R4is an aliphatic, aromatic or heteroaromatic. Y is hydroxyl, methoxy, amino, or alkyl amino. n is an integer from 0 to 4. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a glucocorticoid or thyroid receptor gene such as diabetes, hypercholesterolemia, or obesity using these compounds is also disclosed.