258831-98-0

Basic information

• Product Name: 2H-Indol-2-one, 6-(4-fluorophenyl)-1,3-dihydro-
• CAS NO: 258831-98-0
• Molecular Formula: C14H10FNO
• Molecular Weight: 227.238
• Mol File: 258831-98-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 6-(4-fluorophenyl)-1,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 6-(4-fluorophenyl)-1,3-dihydro-(258831-98-0)
• EPA Substance Registry System: 2H-Indol-2-one, 6-(4-fluorophenyl)-1,3-dihydro-(258831-98-0)

Safety Data

• Hazardous Substances Data: 258831-98-0(Hazardous Substances Data)

Upstream product

• 13939-06-5 molybdenum hexacarbonyl 
• 1765-93-1 4-fluoroboronic acid 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 

Downstream Products

• 760997-68-0 6-(4-fluorophenyl)-3-[1-[3-(3-morpholin-4-yl-propyl)-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrol-2-yl]-meth-(Z)-ylidene]-1,3-dihydroindol-2-one 

Relevant articles and documents

Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions

Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives.

Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors

The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.