258840-07-2

Upstream product

• 258838-84-5 7-Methylthio-2-(tri-n-butyl-stannyl)imidazo[5,1-b]thiazole 
• 90822-25-6 p-nitrobenzyl (1R,5S,6S)-6-<(R)-1-hydroxyethyl>-1-methyl-2-oxo-carbapanem-3-carboxylate 
• 154428-43-0 (4R,5R,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-7-oxo-3-trifluoromethanesulfonyloxy-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Downstream Products

• 352306-88-8 4-Nitrobenzyl (1S,5R,6S)6-((1R)-1-hydroxy-ethyl)-1-methyl-2-[7-methylthio-6-[1-(4-nitrobenzyloxy-carbonyl)pyrrolidin-3-yl]imidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate chloride 
• 352307-89-2 4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxy ethyl)-1-methyl-2-[7-methylthio-6-[2-(4-nitrophenyl)-2-oxoethyl]imidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate bromide 
• 258840-97-0 4-nitrobenzyl(1S,5R,6S)-2-(5-chloro-7-methylthioimidazo[5,1-b]thiazol-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate 
• 1121706-92-0 4-Nitrobenzyl (1S,5R,6S)-2-[6-(4-bromomethyl-benzyl)-7-methylthioimidazo[5,1-b]thiazolium-2-yl]-6-((1R)-1-hydroxyethyl,)-1-methyl-1-carbapen-2-em-3-carboxylate bromide 

Relevant academic research and scientific papers

Synthesis of novel di- and tricationic carbapenems with potent anti-MRSA activity

A new series of 1β-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus was prepared, and their activities against methicillin-resistant Staphylococcus aureus (M

Carbapenem derivatives

Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against β-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof: