258876-65-2

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 70261-81-3 4-(4-nitrobenzyl)-1-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 70261-82-4 4-[(4-methyl-1-piperazinyl)methyl]aniline 
• 3218-36-8 4-Phenylbenzaldehyde 

Relevant academic research and scientific papers

N-[4-(1,1'-biphenylyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines, a new class of synthetic antituberculosis agents active against Mycobacterium avium

Various N-derivatives of 4-(4-thiomorpholinyl)aniline and 4-(4- thiomorpholinylmethyl)aniline were synthesized and tested for in vitro antibacterial activities against Mycobacterium avium CIP 103317 and other mycobacteria including M. tuberculosis CIP 103471. Appropriate substituents were introduced at the nitrogen of aniline portion in order to exploit their potential antimycobacterial activities. Only derivatives with the biphenylylmethyl group bound to the 4-(4-thiomorpholinylmethyl)aniline moiety were found to possess appreciable antibacterial activities against atypical mycobacteria and M. tuberculosis. Several compounds (7c-g and 7j) were two and sixteen times more potent than azithromycin and isoniazid, respectively, in the in vitro assays against M. avium.