258877-85-9Relevant academic research and scientific papers
Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsants
Foster, James E.,Nicholson, Jesse M.,Butcher, Raymond,Stables, James P.,Edafiogho, Ivan O.,Goodwin, Angela M.,Henson, Michael C.,Smith, Carlynn A.,Scott
, p. 2415 - 2425 (1999)
A comparison of enaminones from various unsubstituted and p-substituted benzamides to the analogous benzylamines has been undertaken with the aim of elucidating the essential structural parameters necessary for anticonvulsant activity. Initial studies on methyl 4-N-(benzylamino)-6-methyl-2-oxocyclohex- 3-en-1-oate, 3a, 3-N-(benzylamino)cyclohex-2-en-1-one, 3p, and 5,5-dimethyl- 3-N-(benzylamino)-cyclohex-2-en-1-one, 3r indicated that benzylamines possessed significant anti-maximal electroshock seizure (MES) activity. Evaluation of the analogous benzamides revealed significant differences in anticonvulsant activity, these differences were most probably related to the differences in their three-dimensional structures. (C) 1999 Elsevier Science Ltd.
