25888-68-0 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(Quinolin-2-yl)acetic acid hydrochloride is used as a reagent in the pharmaceutical industry for the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, facilitating the creation of new pharmaceutical entities.
Used in Organic Chemistry:
In the field of organic chemistry, 2-(Quinolin-2-yl)acetic acid hydrochloride is utilized as a versatile reagent that can undergo multiple chemical transformations, contributing to the development of novel chemical compounds and materials.
Used in Pain Management:
2-(Quinolin-2-yl)acetic acid hydrochloride is used as an analgesic agent for its potential therapeutic applications in managing pain. Its ability to alleviate pain has been a focus of research, aiming to develop new treatments for various types of pain conditions.
Used in Inflammation-Related Disorders:
Due to its anti-inflammatory properties, 2-(Quinolin-2-yl)acetic acid hydrochloride is studied for its potential use in treating inflammation-related disorders. Its capacity to reduce inflammation could lead to new therapeutic approaches for a variety of conditions characterized by inflammatory processes.
Handling and Storage:
2-(Quinolin-2-yl)acetic acid hydrochloride is typically handled and stored following standard laboratory protocols for chemical substances, ensuring safety and stability during research and development processes.
Check Digit Verification of cas no
The CAS Registry Mumber 25888-68-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,8,8 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 25888-68:
(7*2)+(6*5)+(5*8)+(4*8)+(3*8)+(2*6)+(1*8)=160
160 % 10 = 0
So 25888-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO2.ClH/c13-11(14)7-9-6-5-8-3-1-2-4-10(8)12-9;/h1-6H,7H2,(H,13,14);1H
25888-68-0Relevant academic research and scientific papers
Studies on Tertiary Amine Oxides. LXXV. Reactions of Aromatic N-oxides with Meldrum's Acid in the Presence of Acetic Anhydride
Yousif, Mohammed Mohammed,Saeki, Seitaro,Hamana, Masatomo
, p. 1680 - 1691 (2007/10/02)
Reactions of quinoline, lepidine, 4-chloro-, 4-methoxy- and 4-morpholino-quinoline 1-oxides (1a-e) with Meldrum's acid (2) in acetic anhydride smoothly occurred at room temperature to afford the corresponding 5-(2-quinolyl)-Meldrum's acids (3a-e) in good yields.On the other hand, when the reactions were carried out in dimethylformamide containing 1.2 eq acetic anhydride the N-ylides (4a-e) were produced; while the reactions of 1a, d, e yielded only N-ylides 4a, d, e, 4b, c were formed along with smaller amounts of 3b, c in the reactions of 1b, c. 3-Bromoquinoline 1-oxide (1f) gave only the N-ylide (4f) and isoquinoline 2-oxide (6) gave the 1-substituted isoquinoline (7) independently of the reaction conditions.Further, 5-alkyl-Meldrum's acids (8a-c) also reacted readily with 1a in acetic anhydride to give the corresponding 2-substituted quinolines (9a-c) in good yields.Heating of 3a, b with conc. hydrochloric acid, 10percent hydrochloric acid or methanol containing 10percent hydrogen chloride gave 2-methylquinolines (10a, b), 2-quinolineacetic acids (11a, b) or their methyl esters (12a, b), respectively.Similarly, 9a-c afforded 2-alkylquinolines (14a-c) in good yields upon being refluxed with conc. hydrochloric acid.Keywords--aromatic N-oxide; Meldrum's acid; 5-(2-quinolyl)-Meldrum's acid; quinolinium-5-Meldrum's acid ylide; 5-(1-isoquinolyl)-Meldrum's acid; 2-alkylquinoline; 2-quinolineacetic acid; nucleophilic reaction; regioselectivity
