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N1-(2,6-Difluoro-3-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H7F2N3O3. It is a nitrophenylacetamide derivative that features a nitro group and two fluorine atoms attached to a phenyl ring. N1-(2,6-Difluoro-3-nitrophenyl)acetamide is recognized for its role in organic synthesis and medicinal chemistry research, where it serves as a building block for the creation of pharmaceuticals and other biologically active compounds. Its potential extends to the development of agrochemicals and materials science, making it a versatile component in various scientific fields. However, due to its hazardous properties, it is crucial to handle N1-(2,6-Difluoro-3-nitrophenyl)acetamide with care, ensuring that only trained professionals work with it in a controlled laboratory environment.

25892-08-4

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25892-08-4 Usage

Uses

Used in Organic Synthesis:
N1-(2,6-Difluoro-3-nitrophenyl)acetamide is used as a building block in organic synthesis for the creation of pharmaceuticals and other biologically active compounds. Its unique structure, which includes a nitro group and fluorine atoms, contributes to the diversity of molecules that can be synthesized, offering a wide range of applications in drug development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N1-(2,6-Difluoro-3-nitrophenyl)acetamide is utilized as a key intermediate in the synthesis of new pharmaceutical agents. Its presence in the molecular structure can influence the pharmacological properties of the final product, making it a valuable component in the design and synthesis of novel therapeutics.
Used in Agrochemical Development:
N1-(2,6-Difluoro-3-nitrophenyl)acetamide may also find applications in the development of agrochemicals. Its chemical properties could be harnessed to create new pesticides or herbicides, contributing to advancements in agricultural productivity and crop protection.
Used in Materials Science:
N1-(2,6-Difluoro-3-nitrophenyl)acetamide's potential applications extend to materials science, where it could be incorporated into the development of new materials with specific properties. Its unique molecular structure may contribute to the creation of materials with improved characteristics for various industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 25892-08-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,8,9 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 25892-08:
(7*2)+(6*5)+(5*8)+(4*9)+(3*2)+(2*0)+(1*8)=134
134 % 10 = 4
So 25892-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2N2O3/c1-4(13)11-8-5(9)2-3-6(7(8)10)12(14)15/h2-3H,1H3,(H,11,13)

25892-08-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,6-difluoro-3-nitrophenyl)acetamide

1.2 Other means of identification

Product number -
Other names 2,6-difluoro-3-nitroacetanilide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25892-08-4 SDS

25892-08-4Relevant articles and documents

Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling

Liu, Longbin,Lee, Matthew R.,Kim, Joseph L.,Whittington, Douglas A.,Bregman, Howard,Hua, Zihao,Lewis, Richard T.,Martin, Matthew W.,Nishimura, Nobuko,Potashman, Michele,Yang, Kevin,Yi, Shuyan,Vaida, Karina R.,Epstein, Linda F.,Babij, Carol,Fernando, Manory,Carnahan, Josette,Norman, Mark H.

, p. 2215 - 2234 (2016/04/26)

One of the challenges for targeting B-RafV600E with small molecule inhibitors had been achieving adequate selectivity over the wild-type protein B-RafWT, as inhibition of the latter has been associated with hyperplasia in normal tissues. Recent studies suggest that B-Raf inhibitors inducing the 'DFG-in/αC-helix-out' conformation (Type IIB) likely will exhibit improved selectivity for B-RafV600E. To explore this hypothesis, we transformed Type IIA inhibitor (1) into a series of Type IIB inhibitors (sulfonamides and sulfamides 4-6) and examined the SAR. Three selectivity indices were introduced to facilitate the analyses: the B-RafV600E/B-RafWT biochemical (bS), cellular (cS) selectivity, and the phospho-ERK activation (pA). Our data indicates that α-branched sulfonamides and sulfamides show higher selectivities than the linear derivatives. We rationalized this finding based on analysis of structural information from the literature and provided evidence for a monomeric B-Raf-inhibitor complex previously hypothesized to be responsible for the desired B-RafV600E selectivity.

PYRIMIDO[5,4-D]PYRIMIDYLAMINO PHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

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Paragraph 0229-0230, (2013/03/26)

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

NEW TRIAZOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

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Page/Page column 39, (2012/07/13)

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4, A,X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

NEW PYRIMIDO[5,4-D]PYRIMIDYLAMINO PHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

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Page/Page column 38, (2012/08/08)

The present invention encompasses compounds of general formula (I), wherein the groups R2 to R4 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors

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Page/Page column 17, (2013/02/27)

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4, A, X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

The electrophilic substitution of some 2,4- and 2,6- dihaloacetanilides

Hanson, James R.,Saberi, Hamid

, p. 699 - 701 (2007/10/03)

The orientation of electrophilic substitution of some 2,4- and 2,6-dihaloacetanilides has been examined by NMR methods. Mixed acid nitration of 2,6-dichloro and 2-chloro-6-methylacetanilides gave predominantly the 3-nitro derivatives.

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