25901-38-6Relevant academic research and scientific papers
Radiopaque contrast media. XXIV. Synthesis and structure activity relationships of new hexaiodinated radiopaque compounds
Felder,Pitre,Fumagalli,Lorenzotti
, p. 912 - 924 (2007/10/06)
The synthesis of a series of new hexaiodinated radiopaque compounds is described. The relationship of structure to tolerability and biliary and urinary excretion was studied. Optimum tolerability was achieved with a compound which has been selected for further investigation as an angiographic contrast agent of the 'dimer' type. Iodoxamic acid showed a high biliary excretion combined with good tolerability, and is being developed as an injectable cholecystographic agent.
