259171-01-2Relevant academic research and scientific papers
Synthesis and biological evaluation of camptothecin substituted norcantharimide derivatives
Lan, Qing,Zhou, Yiqi,Wang, Xianheng,Wang, Yuhe,Zhao, Changkuo
, p. 5752 - 5756 (2020/10/23)
In this paper, a series of novel derivatives of camptothecin substituted norcantharimide was designed by mimic strategy. These compounds were synthesized in moderate yields by directly coupling CPT with N-amino acid norcantharimides. Their cytotoxicity to
Synthesis of l-ascorbic acid-amino acid-norcantharidin conjugates and their biological activity evaluation in vitro
Wang, Xianheng,Wu, Caoyuan,Zhang, Jidong,Zhao, Changkuo,Zhou, Yiqi
supporting information, (2022/01/06)
Three components of L-ascorbic acid, amino acid and functionalized norcantharidins were constructed together in several steps to form 42 norcantharidin derivatives in a high yield. The structure of these synthesized l-ascorbic acid-amino acid-norcantharidin conjugates are determined by 1HNMR, 13CNMR and MS spectrum. The results showed that compounds 6e, 6g, 6j, 6l, 6m, 6b, 6e, 6i, and 6n showed high cytotoxicity to HepG2 and compounds 6b, 6e-g, 6l, 6n, 7b, 7d, 7h, 7i, 7n, 8g, 8i exhibited high cytotoxicity to SW480; Meanwhile, besides 6b, 6e, 6g, and 6k, the other compounds showed less toxic to LO2 at a concentration of 50 μg/mg after 72 h. Compound 6g can induce Mφ-type macrophages derived from mouse bone marrow to polarize to M1-type macrophages.
Synthesis of phosphonodipeptide derivatives of exo-7-oxabicyclo [2.2.1] heptane-2, 3-dicarboxylic anhydride
Zhou, Zheng Hong,Zhang, Zhong Biao,Chen, Ru Yu
, p. 45 - 52 (2007/10/03)
A series of phosphonodipeptide derivatives of norcantharidin (exo-7-oxabicyclo[2.2.1] heptane-2,3-dicarboxylic anhydride) were synthesized and their structures were confirmed by 1H NMR, 31P NMR, IR, MS and elemental analysis.
