259209-21-7

Basic information

• Product Name: 2-HYDROXY-5-METHYLPHENYLBORONIC ACID
• Synonyms: 2-HYDROXY-5-METHYLPHENYLBORONIC ACID;(2-Hydroxy-5-methylphenyl)
• CAS NO: 259209-21-7
• Molecular Formula: C₇H₉BO₃
• Molecular Weight: 151.956
• Mol File: 259209-21-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 343.7±52.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.71±0.58(Predicted)
• CAS DataBase Reference: 2-HYDROXY-5-METHYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-METHYLPHENYLBORONIC ACID(259209-21-7)
• EPA Substance Registry System: 2-HYDROXY-5-METHYLPHENYLBORONIC ACID(259209-21-7)

Safety Data

• Hazardous Substances Data: 259209-21-7(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-5-Methylphenylboronic acid is a chemical compound with the molecular formula C7H9BO3. It is a boronic acid derivative used in organic synthesis and medicinal chemistry as a building block for various pharmaceutical compounds. It is often utilized in Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds. 2-HYDROXY-5-METHYLPHENYLBORONIC ACID has been studied for its potential applications in the development of new drugs and materials due to its ability to facilitate the formation of complex molecular structures. Additionally, it can also be used as a reagent for the selective functionalization of organic molecules.

Upstream product

• 121-43-7 Trimethyl borate 
• 25458-49-5 1-(methoxymethoxy)-4-methylbenzene 
• 7732-18-5 water 
• 106-44-5 p-cresol 
• 104-93-8 p-methylanizole 
• 6627-55-0 2-bromo-p-cresol 
• 127972-00-3 2-methoxy-5-methylphenyl boronic acid 
• 13481-09-9 2-(4-methylphenoxy)tetrahydro-2H-pyran 

Downstream Products

• 1431330-25-4 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl triflate 
• 1312236-77-3 3′,3′′′-(oxybis(methylene))bis(5-methyl-[1,1′-biphenyl]-2-ol) 
• 1312236-75-1 3′,3′′′-(oxybis(methylene))bis(5-methyl-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde) 
• 21991-42-4 6-methyl-1,2,3,4-tetraphenylnaphthalene 
• 124937-51-5 (R)-(+)-tolterodine 
• 7320-51-6 2-methyldibenzofuran 

Relevant articles and documents

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

Reported herein is an enantiodivergent synthesis of chiral biaryls by a chiral phosphoric acid catalyzed asymmetric transfer hydrogenation reaction. Upon treatment of biaryl lactols with aromatic amines and a Hantzsch ester in the presence of chiral phosp

Boron-selective biaryl coupling approach to versatile dibenzoxaborins and application to concise synthesis of defucogilvocarcin M

An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki-Miyaura cross-coupling between o-borylphenols and aryl halides or triflates bearing a 1,8-diaminonaphthalene-protected o-boryl group is reported. A short synthesis

Use of 2-bromophenylboronic esters as benzyne precursors in the Pd-catalyzed synthesis of triphenylenes

ortho-Substituted aryl boronates are introduced as aryne precursors for transition-metal-catalyzed transformations. On treatment with tBuOK and Pd(0), metal-bound aryne intermediates are formed that undergo effective trimerization to form useful triphenylene compounds. For meta-substituted arynes, the 3:1 product ratio in favor of non-C3 symmetric material is indicative of a benzyne mechanism.