259243-63-5Relevant academic research and scientific papers
5-Amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H 3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): Synthesis and characterization of a novel and selective insect GABA receptor radioligand
Meegalla, Sanath K.,Doller, Dario,Silver, Gary M.,Wisnewski, Nancy,Soll, Richard M.,Dhanoa, Dale
, p. 4035 - 4037 (2007/10/03)
Pyrazole 2a is a novel, potent ligand for insect GABA receptors obtained from housefly head membrane preparations (Ki=8 nM). It is 500-fold selective against the mammalian receptor (mouse brain preparations). Its specifically tritiated version (2b) was synthesized by reduction of disulfide 10 with NaBH4 followed by alkylation with [3H 3]-CH3I.
Pyrazolopyrimidines as CRF antagonists
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, (2008/06/13)
A compound of the formula: and the pharmaceutically acceptable acid addition salts thereof, wherein A is NR1R2, CR1R2R11, or C(═CR1R12)R2, NHCR1R2R11, OCR1R2R11, SCR1R2R11, NHNR1R2, CR2R11NHR1, CR2R11OR1, CR2R11SR1or C(O)R2; wherein the rest of the variables are herein below defined, used for inflammatory disorders.
