259256-63-8

Upstream product

• 190078-48-9 (3R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-phenylselanyl-dihydro-furan-2-one 
• 189818-62-0 5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-L-erythro-pentonic acid-γ-lactone 
• 259256-58-1 2-amino-9-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-L-erythro-pentofuranosyl]-6-chloro-9H-purine 
• 259256-57-0 9-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-L-erythro-pentofuranosyl]-6-chloro-2-fluoro-9H-purine 
• 189818-64-2 1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-α-and-β-L-erythro-pentofuranose 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 259256-60-5 9-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-L-erythro-pentofuranosyl]guanine 
• 259256-60-5 2-Amino-9-[(2S,3S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-phenylselanyl-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one 

Relevant academic research and scientific papers

Stereoselective synthesis of β-L-2',3'- dideoxy- and L-2',3'- didehydro-2',3'-dideoxy purine nucleosides

β-L-2',3'-Dideoxy- and L-2',Y-didehydro-2',Y-dideoxy purine nucleosides have been synthesized via a highly stereoselective method of glycosylation by the condensation of L-2-(phenylselenyl)-2,3-dideoxyribose derivative with silylated heterocyclic base.

Anti-human immunodeficiency and anti-hepatitis B virus activities of β-L-2',3'-dideoxy purine nucleosides

β-L-2',3'-Dideoxyadenosine, β-L-2',3'-didehydro-2',3'-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β-L-2',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-HIV (EC50 0.38 μM in PBM cells) and anti-HBV activity (EC50 1.2 μM).